Drug Class: DOACs, Low Molecular Weight Heparin, Unfractionated Heparin

Question 1

What are DOACs?

Answer 1

Direct oral anticoagulants

Question 2

Examples of DOACs

Answer 2

APIXABAN
DABIGATRAN
EDOXABAN
RIVAROXABAN

(-ban)

Question 3

Mode of action of DOACs

Answer 3

DABIGATRAN-> direct thrombin inhibitor
- Prevent fibrinogen-> fibrin
APIXABAN, EDOXABAN, RIVAROXABAN-> direct factor 10a inhibitors
- Prevent prothrombin-> thrombin

Question 4

Contraindications of DOACs

Answer 4

• Use warfarin instead if BMI> 35/40
• Caution if GFR≤ 29
• NO monitoring

Question 5

Example of low molecular weight heparin

Answer 5

DELTAPARIN

Question 6

Mode of action of low molecular weight heparin

Answer 6

• Factor 10a inhibitor

- First choice in cancer patients

Question 7

Contraindications of low molecular weight heparin

Answer 7

• NO monitoring

- NO if GFR < 30

Question 8

Mode of action of unfractionated heparin

Answer 8

• Inhibitor of intrinsic clotting pathway

- Activates Antithrombin

Question 9

Contraindications of unfractionated heparin

Answer 9

• CLOSE MONITORING

- Used if GFR< 30