Drug Class Flashcards

Question

Tropicamide

Answer 1

Muscarinic antagonist

Answer 2

Muscarinic antagonist

Answer 3

Muscarinic antagonist

Answer 4

Muscarinic antagonist

Answer 5

Muscarinic antagonist

Answer 6

Ganglion blocker

Answer 7

Ganglion blocker

Answer 8

Non-depolarizing neuromuscular blocker

Answer 9

Depolarizing neuromuscular blocker

Answer 10

Presynaptic cholinergic antagonist

Answer 11

Presynaptic cholinergic antagonist

Answer 12

Presynaptic cholinergic antagonist

Answer 13

Adrenergic agonist

Answer 14

Adrenergic agonist

Answer 15

Adrenergic agonist

Answer 16

D1 agonist

Answer 17

Beta agonist

Answer 18

B1 agonist

Answer 19

B2 agonist SABA

Answer 20

B2 agonist SABA Uses: asthma, tocolytic* (SC, IV) *Black Box Warning - should be limited to a max of 72 hrs to treat preterm labor

Answer 21

B2 agonist LABA

Answer 22

B2 agonist LABA

Answer 23

Alpha 1 agonist

Answer 24

Alpha 2 agonist

Answer 25

Alpha 2 agonist

Answer 26

Alpha 2 agonist

Answer 27

IGF-1 analog

Answer 28

GH recombinant analog

Answer 29

Somastatin analog

Answer 30

Dopamine agonist

Answer 31

Dopamine agonist

Answer 32

GH receptor antagonist

Answer 33

Synthetic native GnRH

Answer 34

GnRH analog

Answer 35

GnRH analog

Answer 36

GnRH analog

Answer 37

GnRH antagonist

Answer 38

GnRH antagonist

Answer 39

Gonadotropin: purified FSH and LH

Answer 40

Human chorionic gonadotropin

Answer 41

Vasopressin analogs

Answer 42

ADH antagonist V1 and V2 SIADH-induced hyponatremia

Answer 43

Glucocorticoid

Answer 44

Glucocorticoid

Answer 45

Glucocorticoid

Answer 46

Glucocorticoid

Answer 47

Glucocorticoid

Answer 48

Glucocorticoid

Answer 49

Mineralocorticoid

Answer 50

Mineralocorticoid

Answer 51

Glucocorticoid receptor antagonist + Progestin receptor antagonist Use: Abortifacient

Answer 52

Corticosteroid receptor antagonist Androgen receptor antagonist

Answer 53

Inhibitor of adrenal and gonadal steroid synthesis Clinical use: Cushing’s syndrome (non-operable), prostate cancer (resistant to other drugs) CYP450 inhibitor

Answer 54

Corticosteroid receptor antagonist

Answer 55

Corticosteroid receptor antagonist

Answer 56

Estrogen Contraceptive

Answer 57

Estrogen Dominant type after menopause

Answer 58

Estrogen Dominant type during pregnancy

Answer 59

Estrogen Contraceptive

Answer 60

Progestin Contraceptive

Answer 61

Progestin Contraceptive

Answer 62

Progestin Contraceptive

Answer 63

Progestin Contraceptive

Answer 64

Progestin Contraceptive

Answer 65

Progestin Contraceptive

Answer 66

Selective estrogen receptor modulator Antagonist: breast tissue, CNS Agonist: endometrium, bone, liver AE: hot flashes, thromboembolism, endometrial hyperplasia ➡️ inc risk of endometrial CA

Answer 67

SERM Antagonist: breast, CNS and endometrium Agonist: bone, liver

Answer 68

SERM Antagonist: ER in hypothalamus ➡️ inc gonadotropin release ➡️ induces ovulation (ie: treatment of anovulatory cycles in PCOS)

Answer 69

Aromatase inhibitor (steroidal) Competitive, reversible

Answer 70

Aromatase inhibitors (steroidal) Competitive, reversible

Answer 71

Aromatase inhibitors (non-steroidal) Irreversible

Answer 72

Androgen receptor antagonist

Answer 73

5-alpha reductase inhibitor Clinical use: BPH and male-pattern baldness

Answer 74

Progestin Contraceptive

Answer 75

Antiprogestin

Answer 76

PGE2 Cervical ripening, stimulate uterine contractions Use: labor induction Contractions —> obviates the need for oxytocin, hence is an oxytocic

Answer 77

PGE1 Can be used as an abortifacient ➡️ stimulates uterine contractions Contractions —> obviates the need for oxytocin, hence is an oxytocic

Answer 78

Ergot alkaloid Acts in uterine smooth muscle ➡️ inc tone, rate and amplitude of rhythmic contractions Used for controlling postpartum bleeding

Answer 79

NSAID Inhibits prostaglandin synthesis ➡️ delays preterm labor Aka a tocolytic (uterine relaxant)

Answer 80

Primary tocolytic agent Via inhibition of cellular APs = uncoupling of excitation- contraction in my one trial cells

Answer 81

Calcium channel blocker Uses: tocolytic (⬇️ calcium entry into myometrium, ⬇️ MLCK = ⬇️ contractility), antihypertensive, angina

Answer 82

Oxytocin analog Competitive inhibitor at oxytocin receptors Tocolytic

Answer 83

Folic acid antagonist Used off label for early abortion

Answer 84

Antithyroid PTU for first trimester (more stringly protein-bound than methimazole, thus crosses placenta less readily)

Answer 85

Mixture of T4 & T3

Answer 86

Antithyroid, thioamine Preferred over PTU except for in first trimester and in thyroid storm Also has less side effects, lower risk of serious liver injury, longer half life, long duration of action (admin once daily)

Answer 87

Antithyroid Inhibit thyroid hormone release and inhibit organification of iodine (Wolff-Chaikoff effect) Clinical use: thyroid storm sxs improvement

Answer 88

Beta blockers used in the treatment of thyrotoxicosis and thyroid storm (thyroid hormones inc the expression of beta receptors) Propranolol- inhibits conversion of T4 to T3

Answer 89

Used in thyroid storm as they inhibit peripheral conversion of T4 to T3

Answer 90

Sulfonylurea Antidiabetic

Answer 91

Sulfonylurea Antidiabetic

Answer 92

Sulfonylurea Antidiabetic

Answer 93

Sulfonylurea Antidiabetic

Answer 94

Biguanide Antidiabetic

Answer 95

Meglitinide Antidiabetic

Answer 96

Meglitinide Antidiabetic

Answer 97

Thiazolidinedione Antidiabetic

Answer 98

Thiazolidinediones

Answer 99

Alpha-glucosidase inhibitor

Answer 100

Incretin analog Antidiabetic

Answer 101

PTH analog

Answer 102

PTH Antagonist

Answer 103

PTH Antagonist

Answer 104

Bisphosphonate - First generation Not a preferred bisphosphonate for treatment AE of bisphosphonates: ONJ (osteonecrosis of the jaw) (rare at therapeutic doses), subtrochanteric femur fracture (atypical fracture)(long term use = over suppression of bone)

Answer 105

Bisphosphonate - 2nd generation AE: erosive esophagitis Other AE of bisphosphonates: ONJ (osteonecrosis of the jaw) (rare at therapeutic doses), subtrochanteric femur fracture (atypical fracture)(long term use = over suppression of bone)

Answer 106

Bisphosphonate-2nd generation AE: flushing, N/V, flu-like sxs, joint pain and aches, abd pain and discomfort Other AE of bisphosphonates: ONJ (osteonecrosis of the jaw) (rare at therapeutic doses), subtrochanteric femur fracture (atypical fracture)(long term use = over suppression of bone)

Answer 107

Bisphosphonate -3rd generation

Answer 108

Bisphosphonate - 3rd generation IV once yearly Can cause severe hypocalcemia. Also associated with renal toxicity. Other AE of bisphosphonates: ONJ (osteonecrosis of the jaw) (rare at therapeutic doses), subtrochanteric femur fracture (atypical fracture)(long term use = over suppression of bone)

Answer 109

Calcium receptor agonist Enhances sensitivity of the parathyroid calcium sensing receptor (CaSR) to extracellular calcium Major AE: hypocalcemia Contraindications: pts w/ seizure hx, as hypocalcemia lowers the seizure threshold

Answer 110

Phosphate binder Sevelamer hydrochloride is associated w/ high rate of metabolic acidosis while sevelamer carbonate is not

Answer 111

Monoclonal antibody RANKL inhibitor Treatment of postmenopausal osteoporosis: RANKL antagonism inhibits osteoclast formation and activity to suppress bone resorption

Answer 112

Enhances osteoblastic activity and increase bone volume Optimal benefits obtained before the eruption and formation and permanent teeth Toothpaste: sodium fluoride and stannous fluoride

Answer 113

Mineralocorticoid receptor antagonist (use: primary hyperaldosteronism, diuretic in CHF) + Androgen receptor antagonist (hirsutism)

Answer 114

Corticosteroid synthesis inhibitor Inhibits Desmolase which fxs to concert cholesterol to androgens in theca interns cells