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Pharmacology > CHEMOTHERAPY > Flashcards

CHEMOTHERAPY Flashcards

1
Q

S2 phase CCS (cell-cycle specific)

A 
Methotrexate
6MP
6TG
5FU
Capcetabine 
Cytarabine
Gemcitabine
Etoposide
Teniposide
Topotecan
Irinotecan
HU
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2
Q

G1 phase CCS

A

Alkylating agents
Platinum coordination complexes
Anti tumor antibiotics (except bleomycin, which is G2 phase specific)
Nitrosureas (lomustine, carmistine)

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3
Q

G2 phase CCS

A

Bleomycin (an antitumor antibiotic)

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4
Q

M phase CCS

A

Vinca alkaloids: vincristin, vinblastin

Taxanes: paclitaxel, docetaxel

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5
Q

Renal toxicity

A

cisplatin, methotrexate

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6
Q

Hepatotoxicity

A

6MP, busulfan, cyclophosphamide

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7
Q

Pulmonary toxicity

A

bleomycin, busulfan, procarbazine

Other non chemo drug: amiodarone

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8
Q

Cardiac toxicity

A

doxorubicin, duanorubicin

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9
Q

Neurological toxicity

A
  • vincristine*, cisplatin

- cause peripheral neuropathy

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10
Q

Immunosuppressive

A

Cyclophosphamide, methotrexate

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11
Q

Hemorrhagic cystitis

A

Cyclophosphamide: caused by it’s acrolein metabolite

Presents as hematuria

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12
Q

Leukogenic

A

Procarbazine (an alkylating agent)

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13
Q

IL-11

A

⬆️ platelet formation to treat/prevent thrombocytopenia caused by chemo

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14
Q

Filgrastim (G-CSF)

A

⬆️ granulocytes to shorten duration of neutropenia

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15
Q

Sargramostim (GM-CSF)

A

⬆️ granulocytes and macrophages

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16
Q

Erythropoietin

A

⬆️ RBC production to treat anemia’s (esp associated with renal failure)

17
Q

Thrombopoietin

A

⬆️ platelets to treat thrombocytopenia

18
Q

IL-2

A

⬆️ lymphocyte differentiation, ⬆️ NKs (renal call cancer, metastatic melanoma)

Pharmacology (19 decks)

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