Drug Barriers Flashcards
1
Q
What is the primary drug metabolism site in the eye?
A
The Ciliary body.
2
Q
In which part of the crystalline lens is drug metabolized most?
A
In the anterior epithelium. This is because the anterior epithelium of the eye is the most metabolically active part of the lens.
3
Q
Where would you mostly find a charged drug?
A
Once a drug is charged, it is unable to cross lipid membranes. So a charged drug will accumulate in aqueous media.
4
Q
What are the highest and the lowest basal tear flows? What basal tear flow can you expect in a dry eye?
A
Basal tear flow is 0.5μl/min (lowest) - 2.2μl/min (highest)
*In dry eye, the basal tear flow is 0.5μl/min
5
Q
T/F: The Cornea is MAJOR absorption site.
A
True
