Dose-Response Relationship

Question 1

3 Key assumptions of Dose-Response relationships

Answer 1

1- response is proportional to the concentration of the compound at a target site

2- concentration at the target site is related to dose or exposure duration

3- the observed response is directly caused by the administered compound

Question 2

LC50

Answer 2

Lethal concentration causing 50% mortality in a population

Question 3

EC50

Answer 3

Concentration causing a sub-lethal effect in 50% of the population

Question 4

Therapeutic Index

Answer 4

Range of doses where a medication is effective without being lethal

Question 5

Lethal-effects definition

Answer 5

death or quantal (all-or-nothing) outcomes

Question 6

Sub-Lethal effects

Answer 6

Behavioural changes, lesions, biochemical shifts or altered growth rates

Question 7

No Observed Effect Level Concentration (NOEC)

Answer 7

highest tested concentration for which there are no statistically significant differences in effect when compared to control

Question 8

Limits in data analysis

Answer 8

curve fitting accuracy depends on data scatter & sample size