Regulatory Toxicology Flashcards
definition of regulatory toxicology
evaluates the safety of new and existing substances through standardized tests to ensure their safe use and manage risks effectively
Physico-chemical tests for regulation
flammability & solubility
biological effect tests for regulation (5 things)
mammalian toxicity
genotoxicity
carcinogenicity
reproductive toxicity
ecotoxicity
what is hazard identification based on? (3)
chemical structure
physico-chemical properties
toxicity tests
what is risk characterization?
determine exposure probabilities and uncertainty
What is risk management?
evaluate risks versus benefits and enforce production controls
3 types of ecological tests
Acute tests
chronic tests
life cycle assays
Purpose of acute tests
evaluate short-term toxic effects
Purpose of chronic tests
Focus on long-term exposure effects
Purpose of life-cycle assays
Study effects across species life stages
examples of ecotoxicity tests
Algal inhibition test
Daphnia acute toxicity test
Fish toxicity tests
What is an Algal inhibition test
measures cell density growth over 72 hours
What is a Daphnia Acute Toxicity test
determines immobilization due to toxicity
What is a fish toxicity test
includes acute and early life stage studies under controlled water quality
What is the evaluation criteria for ecotoxicity tests?
Specific organism health conditions and mortality thresholds
Validity checks
