Dorzolomide [Trusopt Generic]

Question 1

What is the drug class for Dorzolomide [Trusopt Generic]?

Answer 1

Glaucoma: Carbonic anhydrous Inhibitor Topical

Question 2

What is the MOA for Dorzolomide [Trusopt Generic]?

Answer 2

Reversible inhibition of renal carbonic anhydrase causing increased renal excretion sodium, potassium, bicarbonate and water with decrease production of aqueous humor

Question 3

What are the indications for Dorzolomide [Trusopt Generic]?

Answer 3

Chronic open-angle glaucoma or ocular hypertension

Question 4

What are the common side effects/ADRs for Dorzolomide [Trusopt Generic]?

Answer 4

Eye discomfort, superficial punctate keratitis, ocular allergic reaction, blurred vision, photophobia; possible SJS

Question 5

What are the contraindications for Dorzolomide [Trusopt Generic]?

Answer 5

: Hx severe sulfa allergy, concurrent use with oral carbonic anhydrous inhibitors

Question 6

What are the common drug interactions for Dorzolomide [Trusopt Generic]?

Answer 6

Other carbonic anhydrase inhibitors

Question 7

How should you monitor Dorzolomide [Trusopt Generic]?

Answer 7

IOP

Question 8

Additional comments regarding Dorzolomide [Trusopt Generic]?

Answer 8

caution in hepatic & renal impairment; don’t use eGFR

Question 9

PG Status for Dorzolomide [Trusopt Generic]?

Answer 9

PG C