Brimonidine [Alphagan P]

Question 1

What is the drug class for Brimonidine [Alphagan P]?

Answer 1

Glaucoma: Alpha2 Agonist topical

Question 2

What is the MOA for Brimonidine [Alphagan P]?

Answer 2

Selective agonism for alpha2-receptors causes reduced production of aqueous humor and increased outflow

Question 3

What are the indications for Brimonidine [Alphagan P]?

Answer 3

Chronic open-angle glaucoma, ocular hypertension

Question 4

What are the common side effects/ADRs for Brimonidine [Alphagan P]?

Answer 4

Somnolence, allergic conjunctivitis, hyperemia, eye pruritis, HTN, xerostomia, CNS depression

Question 5

What are the contraindications for Brimonidine [Alphagan P]?

Answer 5

Children less than 2 years old

Question 6

What are the common drug interactions for Brimonidine [Alphagan P]?

Answer 6

Other CNS depressants; Beta-blockers; MAO Inhibitors

Question 7

How should you monitor Brimonidine [Alphagan P]?

Answer 7

IOP

Question 8

Additional comments regarding Brimonidine [Alphagan P]?

Answer 8

benzalkonium chloride absorption by contact lens; t1/2 ~ 2H

Question 9

PG Status for Brimonidine [Alphagan P]?

Answer 9

PG B