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Pharmacology > Dopamine and Serotonin > Flashcards

Dopamine and Serotonin Flashcards

1
Q

Sumatriptan target and function

A

5‐HT1D receptor Agonist - treats migraines

Inhibition of inflammatory mediator release Cerebrovasconstriction

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2
Q

Sumatriptan indication

A

Migraines

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3
Q

Sumatriptan toxicity

A

Coronary vasoconstriction

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4
Q

Sumatriptan contraindication

A

Coronary artery disease

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5
Q

How is the 5-HT1D family of receptors is manipulated to treat migraine?

A

5-HT1D agonists like sumatriptan inhibits inflammatory mediator release with cerebral vasoconstriction

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6
Q

How are 5-HT1A receptors manipulated pharmacologically for treatment of anxiety and depression?

A

5-HT1A agonists like buspirone lead to the activation of post‐synaptic receptors in cortical regions

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7
Q

How are 5-HT3 receptors manipulated pharmacologically for the treatment of chemotherapy-induced nausea and emesis?

A

There are 5-HT3 antagonists like ondansetron that reduce cancer treatment related emesis

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8
Q

How is the 5-HT4 receptor manipulated for treatment of GI disorders?

A

5-HT4 agonists like mosapride will stimulate ACh release in the myenteric plexus which treats things like gastroparesis

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9
Q

Buspirone target and function

A

5-HT1A partial agonist

Activation of post‐synaptic receptors in cortical regions

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10
Q

Buspirone indication

A

Anxiety

Depression

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11
Q

Buspirone toxicity

A

Early increase in anxiety

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12
Q

5-HTP function

A

5-HT precursor

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13
Q

5-HTP indication

A

Depression

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14
Q

Risperidone target and function

A

5-HT2A/2C antagonist and D2/3 antagonist
Suppresses DA release in mesolimbic pathway, but
increases DA release in mesocortical pathway.

Increased activity in mesolimbic causes hallucinations
Decreased activity in mesocortical causes poor emotional affect

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15
Q

Risperidone indication

A

Schizophrenia with psychosis

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16
Q

Risperidone toxicity

A

Weight gain

Akithisia - restlessness

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17
Q

Ondasetron target and function

A

5-HT3 antagonist

Reduces emesis

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18
Q

Ondasetron indication

A

Chemotherapy induced emesis

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19
Q

Ondasetron toxicity

A

None. Well tolerated in patients.

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20
Q

Fluoxetine/Sertraline target and function

A

SSRI

Increases 5-HT (serotonin) post-synaptic receptor activation

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21
Q

Fluoxetine/Sertraline indication

A 
Depression
OCD
Anxiety
Panic disorder
PTSD
Social phobia
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22
Q

Fluoxetine/Sertraline toxicity

A

Sexual dysfunction

Insomnia

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23
Q

Fluoxetine/Sertraline contraindications

A

MAO inhibitors as it can cause “serotonin syndrome”

24
Q

L-DOPA effect

A

DOPA precursor

25
Q

L-DOPA indication

A

Parkinson’s Disease

26
Q

L-DOPA toxicity

A

Arrhythmia

Dyskinesia

27
Q

Carbidopa effect

A

Inhibits AADC in peripheral tissue but cannot cross BBB.

Used with L-DOPA to minimize peripheral DOPA

28
Q

Carbidopa indication

A

Concurrent rx with L‐DOPA to reduce peripheral DA production to protect the CV system

29
Q

Carbidopa toxicity

A

Augments SE of L‐DOPA in CNS

30
Q

Selegiline target and effect

A

MAO-B inhibitor to increase DOPA

31
Q

Selegiline indication

A

Low dose: Parkinson’s Disease

High dose: Depression

32
Q

Selegiline toxicity

A

Potential for hypertensive crisis

33
Q

Bromocriptine target and effect

A

D2 agonist
Post synaptic activation in basal ganglia, may also be neuroprotective so best used early in disease. Leads to increased DOPA

34
Q

Bromocriptine indication

A

Parkinson’s Disease

35
Q

Bromocriptine toxicity

A

Arrhythmia

Dyskinesia

36
Q

Tolcapone target and effect

A

Inhibits COMT breakdown of DOPA

37
Q

Tolcapone indication

A

Parkinson’s Disease

38
Q

Tolcapone toxicity

A

Prolongs and increases effect of L‐DOPA, reduces “off” time, can reduce required L‐DOPA dose

39
Q

Tolcapone contraindication

A

Liver failure

40
Q

Haloperidol target and effect

A

D2 antagonist

41
Q

Haloperidol indication

A

Psychosis

42
Q

Haloperidol toxicity

A

Extra- pyramidal motor disturbances

43
Q

Methylphenidate target and effect

A

Increased DA release in frontal cortex

44
Q

Methylphenidate indication

A

ADHD

45
Q

Methylphenidate toxicity

A

Tachycardia

46
Q

Methylphenidate contraindication

A

Tricyclic antidepressants

47
Q

Metaclopramide target and effect

A

D2 antagonist

48
Q

Metaclopramide indication

A

Chemotherapy‐induced‐ and post‐op nausea and vomiting

49
Q

Metaclopramide toxicity

A

Akathisia

50
Q

Metaclopramide contraindication

A

Long term prescription

51
Q

Trazadone target and effect

A

5‐HT2A/2C antagonist + SSRI

52
Q

Trazadone indication

A

Anxiety

Depression

53
Q

Trazadone toxicity/contraindication

A

Warning of suicidality in young adults at initiation of treatment

Contraindication: MAO inhibitors

54
Q

Mosapride/Cisapride target and effect

A

5‐HT4 receptor agonist

Promotes GI motility

55
Q

Mosapride/Cisapride indication

A

Gastroparesis

56
Q

Mosapride/Cisapride toxicity

A

Prolonged QT syndrom

Pharmacology (74 decks)

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