Chemotherapy III Antitumor Agents Flashcards

1
Q

Doxorubicin MOA

A

Intercalation between base pairs of DNA leading to strand breaks due to inhibition of topoisomerase II

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2
Q

Doxorubicin SE

A
  • Cardiac toxicity : congestive cardiomyopathy.
  • Nausea and vomiting and hair loss, stomatitis.
  • Myelosuppression is dose limiting toxicity.
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3
Q

Topoisomerase I

A

Single strand DNA breaks: relaxation of the strand and re-anneal the strands.

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4
Q

Topoisomerase II

A

Double strand breaks in the DNA: relaxation and re-anneal the strands of DNA.

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5
Q

Doxorubicin Indications

A

Breast cancer, leukemia, sarcoma, Hodgkin’s and Non- Hodgkin’s lymphoma

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6
Q

What is thought to be the mechanism behind cardiotoxicity of doxorubicin?

A

Free radical damage

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7
Q

Irinotecan MOA

A

Topoisomerase I inhibition leading to single strand breaks in the DNA.

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8
Q

Irinotecan SE

A
  • Nausea, vomiting and myelosuppression (dose limiting), stomatitis and hair loss
  • Early cholinergic diarrhea
  • Late secretory diarrhea
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9
Q

Irinotecan Indications

A

GI tract cancers

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10
Q

Bleomycin MOA

A

Binds to DNA, free radical production leading to single and double strand DNA breaks. The bleomycin-iron form is the active species.

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11
Q

Bleomycin SE

A

Pulmonary toxicity is a cumulative toxicity

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12
Q

Bleomycin Indications

A

Testicular cancer

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13
Q

What phase of the cell cycle does bleomycin act in?

A

G2-M phase

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14
Q

What are the uses of prednisone in chemotherapy?

A

Prednisone in high doses for lymphoma and multiple myeloma

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15
Q

What is the use of tamoxifen in chemotherapy?

A

It can be used to treat and prevent breast cancer

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16
Q

Anastrozole Indications

A

Hormone receptor positive breast cancer

17
Q

Flutamide MOA

A

Flutamide inhibits the uptake and binding of the testosterone to specific receptors in hormonally sensitive prostate cancer cells

18
Q

Flutamide Indications

A

Metastatic Prostate Cancer

19
Q

Leuprolide MOA

A

GnRH agonist that leads to inhibition of LH and FSH via negative feedback

20
Q

Leuprolide Indications

A

Prostate cancer

21
Q

What confers multi drug resistance to topoisomerase II inhibitors and tubular inhibitors?

A

P glycoprotein efflux pump

22
Q

How is doxorubicin eliminated?

A

Via bile - dose must be reduced in jaundice

23
Q

What infusion times are more cardiotoxic for doxorubicin?

A

Shorter times

24
Q

What is the max lifetime dose of doxorubicin?

A

400 mg/m^2

25
Q

What should be avoided with bleomycin administration?

A

Do NOT co-administer high concentration oxygen