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Pharmacology > Chemotherapy V Miscellaneous Agents > Flashcards

Chemotherapy V Miscellaneous Agents Flashcards

1
Q

What is the main target of targeted cancer therapy?

A

Tyrosine Kinases

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2
Q

Imatinib Mesylate Target

A

Bcr-Abl fusion protein

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3
Q

What is imatinib mesylate most often used to treat?

A

Chronic Myelogenous Leukemia

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4
Q

Cetuximab MOA

A

Ab that inhibits the EGFR which is over expressed in some types of cancer

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5
Q

Cetuximab Target

A

EGFR receptors

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6
Q

Cetuxumab Indications

A
  • Lung cancer and head and neck cancer

- Colorectal cancer

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7
Q

Erlotinib Target

A

Tyrosine kinase domain associated with EGFR

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8
Q

Erlotinib MOA

A

Inhibition of tyrosine kinase associated with EGFR leading to inhibition of critical cell signaling pathways

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9
Q

Bevacizumab MOA

A

The monoclonal antibody binds to VEGF ligand and presumably decreases the growth of primary cancers and metastatic cancers due to impaired vasculature formation in the tumor.

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10
Q

Transtuzumab MOA

A

Binds and inhibits extracellular domain of the EGFR, her-2/neu

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11
Q

Asparaginase MOA

A

Hydrolyzes L-asparagine leading to inhibition of protein synthesis

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12
Q

Hydroxyurea MOA

A

Inhibits ribonucelotide reductase leading to inhibition of DNA synthesis

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13
Q

All trans retinoid acid (tretinoin) MOA

A

Induces terminal differentiation of the leukemia cells

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14
Q

Arsenic Trioxide Indications

A

Acute Promyelocytic Leukemia

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15
Q

Arsenic Trioxide MOA

A

Allows myeloid differentiation to continue and apoptosis to occur

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16
Q

Besides CML what else can imatinib be used to treat?

A

GI Stromal Tumors with cKIT mutations

17
Q

What mutations will prevent response to cetuximab?

A

KRAS and NRAS

18
Q

What ion can be low from cetuximab therapy?

A

Mg2+

19
Q

Erlotinib SE

A
  • Rash
  • GI symptoms
  • Fatigue
20
Q

What is erlotinib effective at treating?

A

Patients with EGFR activating mutations that lead to lung cancers - ex: adenocarcinoma of lung - often in women non-smokers

21
Q

Sorafenib/Pazopanib/Sunitinib MOA

A

VEGF receptor tyrosine kinase inhibitors

22
Q

Sorafenib/Pazopanib/Sunitinib Indications

A

Renal Cell Cancer

23
Q

What is the main serious SE of Transtuzumab?

A

Cardiac toxicity that is not dose dependent and is reversible

24
Q

Over expression of what indicates good trastuzumab response?

A

Her2/neu overexpression

25
Q

Vemurafenib MOA

A

BRAF inhibitor

26
Q

Vemurafenib Indications

A

Melanoma with BRAF activating mutation

Pharmacology (74 decks)

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