DONE: Drugs: Anticonvulsants > Seizures Flashcards
What three disease process treatment medications are discussed in this lecture?
Myasthenia Gravis (MG)
Seizures
Parkinson’s Disease (PD)
What therapeutic classification of medication is used to treat Amyotrophic Lateral Sclerosis (ALS)?
Rilotec
Study Tip: These medications are not discussed in this lecture but they are discussed in Lecture II.
What therapeutic classification of medication is used to treat Increased Intracranial Pressure (IICP)?
Osmotic Diuretics Ex. Mannitol
Corticosteroids
Barbiturates
Anticonvulsants
Study Tip: These medications are not discussed in this lecture but they are discussed in Lecture II.
What therapeutic classification of medication is used to treat both a CVA and TPA?
Anticoagulants > Ex. Warfarin / Heparin
Platelet Inhibitors > Ex. Aspirin / Plavix
Study Tip: These medications are not discussed in this lecture but they are discussed in Lecture II.
What therapeutic classification of medication is used to treat infections R/T Encephalitis?
Antibiotics - Emergent to start ASAP Pain meds Antivirals Antipyretics
Study Tip: These medications are not discussed in this lecture but they are discussed in Lecture II.
What therapeutic classification of medication is used to treat infections R/T Meningitis?
Antibiotics - Emergent to start ASAP Pain meds Antivirals Antipyretics Study Tip: These medications are not discussed in this lecture but they are discussed in Lecture II.
What therapeutic classification of medication is used to treat Multiple Sclerosis (MS)?
Non-Interferons
Interferons
Study Tip: These medications are not discussed in this lecture but they are discussed in Lecture II.
50% of _______are idiopathic which means that the Drs don’t know what causes them. The other 50% are caused secondary to trauma, anoxia, infection, and CVAs.
Seizures
Study Tip: These all cause some damage to brain.
_______ are caused by abnormal, sudden, excessive discharge of electrical activity within the brain. All these neurons are firing and sending impulses to other parts of the brain.
Seizures
Define Epilepsy?
Chronic Seizure Activity
______ is a chronic condition. There is no cure. Some procedures can interrupt pathways of the brain you could call that somewhat of a cure but it is still a chronic condition.
Epilepsy
Genetic factors Trauma Tumors Circulatory Disorders Metabolic Disorders Toxicity Infections These can cause what neurological disorder?
Seizures
What are the two types of Seizures?
Generalized & Partial
No loss of consciousness.
What type of seizure is this?
Simple partial seizure
Twitching Paralysis Visual disturbances Aura These are the clinical manifestations of what neurological disorder?
Simple Partial Seizure
When symptoms start in one area of the body and then spread this is also known as __________.
Jacksonian Seizures
Sometimes a patient will have an _____ before a seizure this means they have unusual sensations and they help to identify when they are about to have a seizure.
aura
Study Tip: This is what is felt before the seizure.
Altered levels of consciousness.
What type of seizure is this?
Complex partial seizure
A patient with this type of seizure can have some of the same clinical manifestations as simple partial. A patient having this type of seizure can’t interact with the environment.
Complex Partial Seizure
Study Tip: This is because of loss of consciousness.
Automatism, Lip smacking Awkward Gait Repetitive hand movements Fear Anxiety Hallucinations Déjà vu feeling These are the clinical manifestations of what neurological disorder?
Complex Partial Seizure
A _________ seizure involves the entire body.
generalized
If brain activity is normal what happens is you have an electrical impulse that is sent to other parts of the brain. If there are too many impulses the brain will kind of put a _______ on it and will prevent it from being sent to other parts of the brain. In people with ______ those bursts of activity from the cortex are not modulated.
damper
epilepsy
Electrical impulses originating in the cerebral cortex and going on to deeper brain structures and it’s not being forwarded from there is considered _______ brain activity.
Normal
Electrical impulses originating in the cortex and going down in to the deeper areas of the brain and then being sent on so they are just firing all over the brain is considered ______ brain activity.
Abnormal
_______ is a problem in the brains wiring and it can be a really devastating condition to have.
Epilepsy
Seizure medications are also called ________ these are used to depress abnormal neuronal discharges and prevent the spreading of electrical activities that the brain is not suppressing on own, so its not __________ the cause its just preventing a seizure from occurring.
anticonvulsants
eliminating
This is used to depress abnormal neuronal discharges and prevent the spread of seizures to adjacent neurons.
Anticonvulsants
Study Tip: These medications prevent seizure, and do NOT eliminate the cause.
Anticonvulsant drugs generally act by stabilizing nerve cell membranes and preventing abnormal electric impulses from the seizure _______ to other cortical areas.
These drugs generally act by stabilizing _______ membranes and that makes them __________.
focus
nerve cell
CNS depressants
Diplopia Drowsiness Double vision Ataxia Slowed mental processes What therapeutic classification of medication has these side effects?
Anticonvulsants
Study Tip: Slowed mental processes means it’s probably not safe for these patient’s to operate a car.
Most of these medications work by preventing ______ influx or ______ influx or by increasing ______ which is the chief inhibitory neuro transmitter so it gives the brain more of this substance and inhibits transmission.
sodium
calcium
GABA
What is the chief inhibitory neurotransmitter released during a seizure?
GABA
What does GABA mean?
Gamma-Amino Butyric Acid
Begin with a single dose of the medication. The dosing depends on the patient’s age, weight, type of seizures, how often seizures are occurring, and what the cause of the seizure was. The nurse will start with this dose and increase it until the desired effect happens or the degree of side effects become worse than the benefits that the patient is achieving.
This is the principle drug therapy for what therapeutic classification of medications?
Anticonvulsants
______ levels of anticonvulsant drugs need to be monitored. There are many drugs that should be monitored. It is up to the RN to be AWARE of the levels that need to be monitored for each medication.
Serum
Therapeutic ranges that’s what it’s called when a drug is supposed to be say between 1.0 and 2.0 of the blood serum level of the drug, with anticonvulsants these ranges are only used as a guide. Patient might need a therapeutic level of ______ to be effective or therapeutic. If the patient’s seizures are well controlled but the drug level was LESS than the therapeutic range it’s okay it means we titrated/adjusted the dose to give the desired effect to control seizures.
2.5
Many of the newer anticonvulsant drugs on the market don’t need to have the therapeutic drug levels monitored because the range is so big that it isn’t essential. A ______ range is harder to keep a blood level within that range.
NARROW
If the seizure control isn’t achieved with a single drug we might need to change the _______, the _______, or we might add another _______. About a third of patients require combination therapy.
dosage
timing
drug
When giving a woman an anticonvulsant medication what 4 indications must be taken into consideration that can affect seizure activity?
Hormonal fluctuations Puberty Menstruation Pregnancy Menopause
Study Tip: This is very IMPORTANT.
Some of the anticonvulsants have _________ effects so pregnant women can’t take them, this is another thing to keep in mind.
teratogenic
A single dosage of anticonvulsant drug is based on the patient’s age, weight, type, frequency, and cause. The nurse will increase the dose to achieve therapeutic range or until toxic side effects occur. Some patient’s may need a __________ regimen.
combination
What are the 4 therapeutic classifications of anticonvulsants?
Hydantoins
Barbiturates
Valproates
Benzodiazepines
What is the name of the most commonly used Hydantoin therapeutic classification of anticonvulsant medication?
Phenytoin / Dilantin
Study Tip: Remember the “toin” > HYDANTOIN. This medication is covered in-depth in this exam.
What is the name of the most commonly used Barbiturate therapeutic classification medication?
Phenobarbital / Luminal
Study Tip: Remember the “barbital” > BARBITURATE. This medication is covered in-depth in this exam.
What is the name of the most commonly used Valproate therapeutic classification of anticonvulsant medication?
Valproic Acid / Depakote
What are the 3 names of the most commonly used Benzodiazepine therapeutic classification of anticonvulsant medication?
Diazepam / Valium
Lorazepam / Ativan
Clonazepam / Klonopin
Study Tip: Remember the “PAM”. This medication is covered in-depth this exam.
What is the name of the most commonly used mood stabilizer for anticonvulsant medication therapy?
Carbamazepine / Tegretol
Study Tip: This medication is covered in-depth in this exam.
What is the name of the most commonly used analgesic adjunct and mood stabilizer for anticonvulsant medication therapy?
Gabapentin / Neurontin
What is the name of the most commonly used adjunct treatment for anticonvulsant medication therapy?
Lamotrigine / Lamictal
What is the name of the most commonly used pyrrolidines for anticonvulsant medication therapy?
Levetiracetam / Keppra
Study Tip: This medication is covered in-depth in this exam.
What is the name of the most commonly used analgesic therapeutic classification of anticonvulsant medication?
Pregabalin / Lyrica
Study Tip: This medication is covered in-depth in this exam.