Dobutamine

Question 1

Dobutamine

Class

Answer 1

Sympathomimetic, inotropic agent.

Question 2

Dobutamine

Mechanism of Action

Answer 2

Synthetic catecholamine. Increases myocardial contractility and stroke volume, increases cardiac output. Minimal chronotropic activity.

Question 3

Dobutamine

Indications

Answer 3

Cardiogenic shock, CHF (when an increase in cardiac output without an increase in heart rate is desirable), left ventricular dysfunction. Often used in conjunction with other drugs

Question 4

Dobutamine

Contraindications

Answer 4

Tachyarrhymias

Question 5

Dobutamine

Adverse Reactions

Answer 5

May increase infarct size in patients with MI, headache,

arrhythmias, hypertension, and PVCs.

Question 6

Dobutamine

Drug Interactions

Answer 6

Incompatible with sodium bicarbonate and furosemide. Beta-blockers may blunt inotropic effects.

Question 7

Dobutamine
Dosage and Administration
Adult

Answer 7

IV infusion at 2 – 20 mcg/kg/min titrated to effect

Place 250 mg in 500 ml of D5W or NS for a concentration of 0.5 mg/ml

Question 8

Dobutamine
Dosage and Administration
Pediatric

Answer 8

2 – 20 mcg/kg/min titrated to effect

Question 9

Dobutamine

Onset

Answer 9

2-10 minutes

Question 10

Dobutamine

Peak Effects

Answer 10

10-20 minutes

Question 11

Dobutamine

Duration

Answer 11

1-2 minutes after infusion has stopped