Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

PRE REG > DOAC > Flashcards

DOAC Flashcards

1
Q

What is the dose of dabigatran FOR AF if aged under 80 years old?

A

150mg bd

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the dose of dabigatran FOR AF if aged over 80 years old/taking verapmail?

A

110mg bd

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the dose of dabigatran following a DVT/PE

A

Following parenteral anticoagulant for at least 5 days, 150mv bd

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

When should a dose of 110mg bd for dabigatran be considered?

A

If bleeding risk high: 75-80 years, gord, oesaphagitis, gastritis, crcl 30-50ml/min

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

When is dabigatran contraindicated

A

Hypersensitivity, significant risk factor for bleeding, active bleeding, in combination with anticoauglant, concomitant treatment with ketoconazole, itraconazole, cyclosporin, dronedarone, prosthetic heart valves

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

How should dabigatran be administered?

A

With/after food. swallwowed who, do not open capsules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Can dabigatran go into a compliance aid?

A

No

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

How long after a missed dose can dabigatran be taken?

A

Missed dose may be taken up to 6 hours
prior to next scheduled dose

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What must be monitored with regards to renal function and dabigatran?

A

Baseline renal function before initiation.
Contraindicated in CrCl<30ml/min

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Is dabigatran indicated in hepatic impairment?

A

Not recommended in patietns with elevated
liver enzymes >2xULN
CI in patients with hepatic impairment or
liver disease expected to impact on survival

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the antidote for dabigatran

A

Idarucizumab

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the dose of rivaroxiban for AF

A

20mg OD
CrCl 15-
59ml/min 15mg

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is the dose of rivaroxiban for DVT/PE

A

15mg BD for 21
days, then 20mg
daily (minimum
3 months)
CrCl 15-
49ml/min 15mg
BD for 21days
then 20mg OD or
15mg OD if risk
of bleeding > risk
of recurrent DVT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is the dose of rivaroxiban for ACS

A

2.5mg BD with
aspirin alone
OR
Aspirin + clopidogrel
Use with caution if
>75 years or if <60kg

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are the contraindications for rivaroxiban?

A

Hypersensitivity
Significant risk factor for major bleeding
Active bleeding
In combination with an anticoagulant (except when
switching)
Pregnancy & breastfeeding
Concomitant treatment of ACS with antiplatelet therapy in patients with prior stroke or tia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Should rivaroxiban be taken with food

A

15mg and 20mg dose must be taken with food to increase
absorption. May be crushed if required (off license)

17
Q

Can rivaroxiban be used in compliance aids?

A

Yes

18
Q

What should happen in the case of a missed rivaroxiban dose?

A

OD dosing: Missed dose should be taken immediately and
then continued on the following day.
Do not double a dose within the same day to make up for
a missed dose (except if taking 15mg BD for DVT/VTE
treatment, take 2x15mg immediately to ensure a dose of
30mg daily. Continue 15mg BD intake the following day

19
Q

What is the monitoring requirements for rivaroxiban?

A

Baseline renal function before initiation.
Not recommended if CrCl<15ml/min
Use with caution if CrCl 15-29ml/min

20
Q

Can rivaroxiban be give in hepatic impairment

A

Use with caution as requires hepatic metabolism.
CI hepatic disease associated with coagulaopathy &
clinically relevant bleeding risk.

21
Q

What is the antidote for rivaroxaban

A

No antidote

22
Q

What us the dose of apixaban for af

A

5mg BD
2.5mg BD if CrCl 15-
29ml/min
2.5mg BD if 2+ of the
following:
Age ≥ 80 yrs
Weight ≤ 60kg
Serum Cr ≥
133μmol/

23
Q

What is the dose of apixaban for dvt/pe

A

Treatment PE/DVT 10mg
BD for 7 days then 5mg
BD
Prevention DVT/PE after
6months treatment dose
2.5mg BD
Individualised treatment
duration

24
Q

What are the contrainidcations for apixaban

A

Hypersensitivity
If a significant risk factor for major bleeding
Active clinically significant bleeding
In combination with an anticoagulant (except
when switching

25
Q

When should apixaban be taken

A

take with or without food.
May be crushed and suspended (off license)

26
Q

What should happen in the case of a missed dose of apixaban

A

Missed doses should be taken immediately and
then continued with BD as before.

27
Q

What are the recommendations for renal impairment and apixaban

A

baseline renal function before initiation.
Not recommended if CrCl<15ml/min
Use with caution if CrCl 15-29ml/min

28
Q

Should apixaban be used in hepatic impairment?

A

Not recommended in severe hepatic impairment
as requires hepatic metabolism.
CI – hepatic disease associated with coagulopathy
and clinically relevant bleeding risk.
Caution in patients with mild or moderate hepatic
impairment, elevated ALT/AST >2xULN, total
bilirubin>1.5xULN.
Check baseline LFTs prior to initiation

29
Q

When should a dose reduction of apixaban be considered?

A

consider dose reduction ≥ 80yrs to 2.5mg BD if
one of the following also applies: weight <60kg,
serum creatinine >133μmol/L

30
Q

What is the dose of edoxaban for af

A

0mg OD
30mg OD if 1+ of the
following:
CrCl 15-50ml/min
Weight <60Kg
Concurrent Rx for:
ciclosporin, dronedarone,
erythromycin,
ketoconazole

31
Q

What is the dose of edoxaban for dvt/pe

A

Following parenteral
anticoagulant for at
least 5 days – 60mg OD
Individualised
treatment duration

32
Q

What are the contraindications for edoxaban

A

Hypersensitivity
If a significant risk factor for major bleeding
Active bleeding
In combination with an anticoagulant (except when
switching)
Pregnancy and breastfeeding
Uncontrolled severe hypertension

33
Q

What should be done in the case of a missed dose of edoxaban

A

Missed dose should be taken immediately and then
continued once daily as before.
Do not double dose within the same day to make up
for missed doses

34
Q

What are the recommendations for edoxaban with regards to renal function

A

Baseline renal function before initiation.
Not recommended if CrCl<15ml/min

35
Q

Should edoxaban be used in hepatic impairment?

A

Not recommended in severe hepatic impairment as
requires hepatic metabolism.
CI – hepatic disease associated with coagulopathy
and clinically relevant bleeding risk.
Caution in patients with mild or moderate hepatic
impairment, elevated ALT/AST >2xULN, total
bilirubin>1.5xULN.
Check baseline LFTs prior to initiation and
periodically if treatment beyond 12 months

36
Q

Which doac has black triangle status

A

edoxaban

PRE REG (24 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions