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Micro > DNA viruses and TSE > Flashcards

DNA viruses and TSE Flashcards

1
Q

Anterograde Transport

A

from negative to positive ends of microtubules

cell body –> axons

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2
Q

Retrograde transport

A

from positive to negative ends of mts

axon–>cell body

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3
Q

Virus Movement is dependent on…

A

Microtubules! interact with motor complexes

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4
Q

Definition of Neuroinvasive

A

Can enter the CNS after infecting a peripheral site

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5
Q

Definition of Neurovirulent

A

can cause disease by damaging nerve tissue

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6
Q

What are the 4 Herpesvirus infections of the CNS?

A

HSV encephalitis
VZV virus
CMV
HepB

virus - linear dsDNA

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7
Q

What is the most common form of sporadic fatal encephalitis in adults

A

HSV-1 ENCEPHALITIS! (HSE)

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8
Q

What part of the brain is most often involved in HSE? diagnostic feature on brain?

A

Temporal Lobe

Necrosis and punctate hemorrhages

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9
Q

What main feature differentiates VZV from Herpesvirus?

A

VZV have a viremic phase!

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10
Q

What is used to treat VZV infections in CNS? why?

A

famiclovir or valacyclovir–higher bioavailability than acyclovir

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11
Q

What is the leading cause of non hereditary deafness in children?

A

Congenital CMV

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12
Q

What are the characteristics of polyomaviruses?

A

circular, dsDNA, non enveloped, use host machinery for replication
JCVirus, BK Virus, SV40

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13
Q

JC Virus is most often associated with…?

A

Progressive Multifocal Leukoencephalopathy (PML) in immunocompromised individuals

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14
Q

PML clinical features?

A

symptoms indicative of focal cerebral involvement (personality alterations, intellectual deficits, loss of motor skills, sensory loss) Rapid progression. Rare remissions.
Lesions in white matter! because of demylin of nerve cells

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15
Q

What causes the PML lesions?

A

Loss of myelin due to virus replication in oligodendrocytes. NO inflammation.

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16
Q

What is the infectious agent in Transmissible spongiform encephalopathies?

A

Protein!!!

17
Q

Features of Creutzfeldt-Jakob?

A

most common human TSE

sporadic, familial, iatrogenic, variant

18
Q

CJD neuropathology

A 
spongiform degeneration
astrocytosis
cerebral atrophy
neuronal vacuolization
amyloid plaques
LACK inflammation
19
Q

What is the prion conformation change?

A

From alpha-helical to beta sheet! critical!

20
Q

Role of PRNP genotype in susceptibility to prion diseases?

A

Having MM does not guarantee you have variant CJD but 100% of the people with variant CJD have those alleles.

21
Q

What clinical features are caused by TSE?

A

impaired cognitive function, ataxia, progressive degeneration of neurological function leading to death

Micro (10 decks)

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