DNA viruses Flashcards
All enveloped viruses acquire their envelope from plasma membrane except for
Herpes virus (from nuclear membrane)
Purified nucleic acids of most dsDNA except for ______ are infectious
Poxviruses and HBV
Only live attenuated vaccine that may be given to HIV positive patients
MMR
DNA viruses
DNA viruses are HHAPPPPy viruses Hepadna Herpes Adeno Pox Parvo Polyoma Papilloma
All DNA viruses have double-stranded DNA except
Parvovirus
All DNA viruses have linear DNA except
Papilloma, polyoma, hepadna
All DNA viruses are icosahedral except
Poxvirus
All DNA viruses replicate in the nucleus except
Poxvirus (cytoplasm)
Condition with bright red cheek rash (slapped cheeks) with fever coryza and sore throat
Erythema Infectiosum (Fifth Disease)
Etiology of Erythema Infectiosum (Fifth Disease)
Parvovirus B19
Causes transient but severe aplastic anemia in children sickel cell anemia, thalassemia or spherocytosis
Parvovirus B19
Aplastic crisis
Fetal infection caused by Parvovirus B19
Hydrops fetalis (2nd trimester)
Only virus with fiber (Penton fiber)
Adenovirus
Causes hemorrhagic cystitis
Adenovirus
Papilloma virus infects squamous cells and induce formation of cytoplasmic vacuole
Koilocytes
What genes in Papilloma virus encode proteins that inactivate tumor suppressor genes
genes E6 and E7
HPV that causes skin and plantar warts
HPV 1-4
HPV that causes genital warts (condylomata acuminata) and respiratory tract papillomas
HPV 6 and 11
HPV that causes carcinoma of cervix, penis and anus
HPV 16,18, 31,33
DOC for HPV
Genital warts : Podophyllin
Skin warts: Liquid nitrogen
Plantar warts: Salicylic acid
Causes progressive multifocal leukoencephalopathy (PML) in patients with AIDS
JC Polyoma virus
Causes hemorrhagic cystitis and nephropathy in patients with solid organ and bone marrow transplant
BK Polyoma virus
Site of latency period of herpes virus
HSV-1 - trigeminal ganglia
HSV-2 Lumbosacral ganglia
DOC for herpes
Acyclovir
Site of latency period for Varicella zoster virus
Dorsal root ganglia
Condition where in all stages of the disease are present at a single time
Varicella
A syndrome that is a complication of varicella
Reye’s syndrom
A condition where in there is involvement of geniculate ganglion causes facial nerve paralysis
Ramsay hunt syndrome / Herpes zoster oticus
Blueberry muffin syndrome
CMV
Congenital rubella
Disseminated Neuroblastoma
Causes Heterophil-negative mononucleosis
CMV
DOC for CMV
Ganciclovir
3 causes of mononucleosis
CMV & Toxoplasmosis ( heterophil negative)
EBV (heterophil positive)
Virus associated with burkitt’s lymphoma
EBV
Virus associated with nasopharyngeal CA in chinese people and hairy leukoplakia in AIDS patient
EBV
Virus associated with Kaposi’s sarcoma
Human Herpesvirus -8
Largest virus
Smallpox
Disease with pinkish papular skin lesions with an umbilicated center
Molluscum contagiosum
Tx. Cifodovir
Only DNA virus that produces DNA by reverse transcription with mRNA as the template
Hepatitis B virus
DOC of Hepatitis virus
Interferon alpha
Lamivudin
Associated with Polyarteritis nodosa
Hepatitis B
