DNA Damage and Repair

Question 1

DNA damage via exogenous sources include ________.

Answer 1

Environmental sources such as radiation

Question 2

DNA damage via endogenous sources include _________.

Answer 2

Intracellular processes, ROS, Alkylation, Hydrolysis

Question 3

Pol delta is responsible for _____.

Answer 3

Replication of DNA on lagging strand

Question 4

Pol epsilon is responsible for _________.

Answer 4

Replication of DNA on leading strand

Question 5

Where are the two checkpoint in the cell cycle?

Answer 5

1. Prior to entrance into S phase (if DNA contains damage)
2. Prior to entrance into M phase (breaks or damage sites in DNA)

Question 6

What are the phases of the cell cycle?

Answer 6

G1- Cell growth, duplication of organelles, Prep for DNA replication

S- DNA replication

G2- Cell Growth, Duplication of Organelles, Prep Cell Division

M- Mitosis