DNA and Chromosomes Flashcards

1
Q

Nucleic acids are polymers of what

A

Nucleotides

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2
Q

What are connected by phosphodiester bonds to form what

A

A DNA strand

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3
Q

Two DNA strands interact to form a what

A

Double helix

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4
Q

What interaction takes place between what types of bonds between base pairs

A

Hydrogen bonds

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5
Q

A to T has how many hydrogen bonds

A

2 hydrogen bonds

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6
Q

G to C has how many hydrogen bonds

A

3 hydrogen bonds

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7
Q

The two DNA strands are

A

Antiparallel and complementary

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8
Q

DNA carries genes which is what

A

Information necessary to synthesize a polypeptide

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9
Q

Each gene encodes a unique _________

A

Protein

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10
Q

All cells have DNA in what

A

Chromosomes

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11
Q

What are chromosomes

A

Large pieces of DNA that contain hundreds or thousands of genes

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12
Q

Prokaryotes have what shaped chromosomes

A

Circular

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13
Q

Eukaryotes have multiple what shaped chromosomes

A

Linear

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14
Q

Many eukaryotic species have more than one type of

A

Chromosome

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15
Q

Humans have how many different chromosomes with two copies of each in the nucleus

A

23 (46 total)

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16
Q

Each pair of chromosomes (homologs) contain the same set of genes but carry different what

A

Alleles

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17
Q

22 pairs of

A

Chromosomes

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18
Q

1 pair of what

A

Sex chromosomes

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19
Q

Life requires that parent cells pass genetic information to who

A

to the next generation

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20
Q

The cell cycles includes the processes copying and separating chromosomes amoung what

A

Two daughter cells

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21
Q

Copying and separating the chromosomes requires what

A

specialized chromosomal sequences and structures

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22
Q

What do chromosomes have where DNA synthesis begins?

A

Origin of replication

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23
Q

Eukaryotic chromosomes also have

A

a centromere

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24
Q

What is a centromere

A

a region of DNA necessary for chromosome separation

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25
What attaches to centromeres
Microtubules
26
Which pair is easier to break
A/T base pairs
27
What is the ori
A region of DNA with a high A/T content
28
When does replication occur
interphase
29
Where does repliation begin
The ori
30
Replication completes before what
mitosis
31
What does mitosis do
Separates the chromosome copies
32
When a chromosome is copied in interphase, where do the copies remain attached
The centromere
33
The two copies are called
Sister chromatids
34
When do sister chromatids detatch
anaphase
35
Are sister chromatids identical or different
identical
36
Eukaryotic chromosomes also contain
Telomeres
37
What are telomeres
Regions of repeated DNA seqeunces and specific proteins at the end of a linear chromosome
38
What do telomeres do
Protect the ends of the chromosomes from degradation by cellular enzymes
39
Are telomeres long or short
Long
40
What is shortening of telomeres associated with
aging and some diseases
41
Chromosomes alternate compacting depending upon what
The portion of the cell cycle
42
Interphase/non-dividing =
More loosely packed
43
Mitosis =
more tightly packed to make it easier to seperate
44
Chromosome packaging is necessary for what
for cell division
45
Chromosomes requires various types of what
DNA-binding proteins
46
What are histones
A major type of DNA-packaging proteins
47
What is a mixture between DNA and packaging proteins called
Chromatin
48
DNA strands wrap around histones to form what
Nucleosomes
49
Nucleosomes associate with each other to form what
Chromatin Fiber
50
Chromatin fibers are folded into loops to do what
Compact the chromosome
51
Packaging proteins can be inactivated which allows what
the chromosomes to relax
52
Compaction state depends on what
the cell cycle stage
53
Relaxed portions of a chromosome are called what
Euchromatin
54
Compacted regions of chromosomes are called
Heterochromatin
55
Centromeres and telomeres remain as what
heterochromatin
56
When a region is tightly compacted, genes in that region are what
Not expressed
57
Proteins involved in transcription cannot bind
DNA
58
Whole regions of chromosomes can be
Turned off
59
Protein compaction must be what for these genes to be expressed
relaxed
60
Can cells control which genes are expressed or not expressed based on chromosome structure?
Yes