DM-Week 1

Question 1

Hepatic stem cells that contribute to liver regeneration reside in which of the following locations?

Answer 1

Canal of Herring

Question 2

In contrast to other organs in the GI system, the wall of the gall-bladder lacks which of the following layers?
A. Adventitia
B. Lamina propria
C. Muscularis Externa
D. Serosa
E. Submucosa

Answer 2

E. Submucosa

Question 3

The pancreas delivers an alkaline pH fluid to the duodenum that helps to neutralize the acidity of gastric juice, protect the small intestine, and provide an optimum pH for hydrolytic enzyme present in the lumen. What portion of the exocrine pancreas secretes most of this bicarbonate and sodium rich alkaline fluid?
A. Intercalated ducts
B. Interlobular ducts
C. Intralobular ducts
D. Pancreatic duct of Santorini
E. Pancreatic duct of Wirsung

Answer 3

A. Intercalated ducts

Question 4

Which of the following enzymes catalyzes the conversion of pancreatic proenzymes to active enzymes within the lumen of the duodenum?
A. Alkaline phosphatase
B. Elastase
C. Maltase
D. Phospholipase
E. Trypsin

Answer 4

E. Trypsin

Question 5

Increased serum levels of alkaline phosphatase are an indicator of injury to which of the following tissues/structures?
A. Bile ducts
B. Centrilobular hepatocytes
C. Islets of Langerhans
D. Pancreatic exocrine acini
E. Periportal hepatocytes

Answer 5

A. Bile Ducts (duct enzymes)

Question 6

Type 1 Glycogen Storage Disease and Enzyme Deficiency:

Answer 6

Von Gierke, Deficiency of Glucose 6-phosphatase

Question 7

Type II Glycogen Storage Disease and Enzyme Deficiency

Answer 7

Pompe Disease, Deficiency of alpha-Glucosidase

Question 8

Type III Glycogen Storage Disease and enzyme deficiency

Answer 8

Cori Disease, Deficiency of debranching enzyme

Question 9

Type IV Glycogen storage disease and enzyme deficiency

Answer 9

Anderson disease, deficiency of branching enzyme

Question 10

Type V Glycogen storage disease and enzyme deficiency

Answer 10

McArdle disease, deficiency in myophosphorylase (muscle)

Question 11

Type VI Glycogen storage disease and enzyme deficiency

Answer 11

Hers Disease, deficiency of liver phosphorylase

Question 12

Type VII Glycogen storage disease and enzyme deficiency

Answer 12

Taurui Disease Deficiency of PFK-1

Question 13

GSD indicated:
Growth failure (Doll face); twitching and seizures; hepatonephromegaly (glycogen deposits), lactic acidosis

Answer 13

Von Gierke Disease

Question 14

GSD Indicated:
Cardiomegaly, floppy infant, lysosomal glycogen deposits in the heart

Answer 14

Pompe Disease

Question 15

GSD indicated:
Hepatomegaly (limit dextrin/abnormal glycogen), progressive muscle weakness, hypoglycemia

Answer 15

Cori Disease

Question 16

GSD Indicated:
Hepatomegaly, Cirrhosis, hypoglycemia, elevated AST and ALT

Answer 16

Anderson disease

Question 17

GSD indicated:
Muscle cramps and fatigue during exercise, rhabomyolysis and brown urine, “second wind” effect

Answer 17

McArdle Disease

Question 18

GSD indicated:
Hypoglycemia and hepatomegaly

Answer 18

Hers Disease

Question 19

GSD indicated:
Muscle cramps and fatigue during exercise, Rhabdomyolysis and brown urine, Hemolysis

Answer 19

Tarui Disease