DM

Question 1

DM - what does it stand for? What was it previously known as?

Answer 1

• DM = degenerative myelopathy
• previously known as CDRM (chronic degenerative radiculomyelopathy)

Question 2

Prevalence

Answer 2

• common in the German Shepherd dog

Question 3

Presentation

Answer 3

• chronic progressive hindlimb ataxia
• usually occurs at 6-9y
• usually progresses over 9months to a stage requiring euthanasia on grounds of QoL
• non-painful condition

Question 4

Genetic component & gene screening

Answer 4

• there is a genetic component to DM with a link to the SOD1 (superoxide dismutase) gene
• gene screening results in a number of false postiive cases and so can’t be used as a definitive diagnostic test or definitive predictor of development of DM

Question 5

Diagnosis

Answer 5

• by exclusion (IVDD protrusion)
• no signs yet identified on MRI

Question 6

Tx

Answer 6

• no effective therapy
• physiotherapy has been shown to slow the rate of deterioration but not prevent