Diverticular disease Flashcards
What is diverticulosis?
The presence of diverticula outpouchings (diverticulosis concerns MULTIPLE) of the colonic mucosa and submucosa through the muscular wall of the large bowel. They are NOT INFLAMED.
What are pseudo- and true diverticula?
True is an outpouching of all three layers of the GI wall; Pseudo is an outpouching through the muscularis.
What is diverticular disease?
Diverticulosis associated with complications e.g. haemorrhage, infection, fistulae. This includes diverticulitis i.e. SYMPTOMATIC diverticulosis.
What is diverticulitis?
Acute inflammation and infection of colonic diverticulae.
What is Hinchey classification of acute diverticulitis? (x4)
Ia: phlegmon (localised, acute inflammation), Ib and II: localised abscesses, III: perforation with purulent peritonitis (purulent refers to containing pus), IV: faecal peritonitis.
What are the risk factors of diverticulitis? (x4)
Low fibre diet, obesity, smoking, family history, NSAID use.
Why may low fibre diet cause diverticular disease?
Leads to loss of stool bulk, so high colonic intraluminal pressures are needed to propel the stool, leading to herniation of the mucosa and submucosa through the muscularis.
What is the location of diverticular disease? (x2 points)
(1) Diverticulae are most common in the sigmoid and descending colon but can be right sided. They are absent from the rectum. (2) Occurs usually at sites of entry of perforating arteries, as these are the weakest areas of colonic wall.
What is the epidemiology of diverticular disease: Prevalence? Age? Country?
60% in industrial countries will develop diverticula in the colon. Rare below 40 years old. Right-sided more common in Asia.
What are the complications of diverticular disease? (x7)
Diverticulitis, pericolic abscess, perforation, faecal peritonitis, colonic obstruction, fistula formation (bladder, small intestine, vagina), haemorrhage.
In diverticular disease abscess: What should you consider if there are no localising signs?
Abscesses tend to have localising signs e.g. pain in one quadrant, boggy rectal mass. If there are no localised signs, remember the saying: PUS SOMEWHERE, PUS NOWHERE = PUS UNDER THE DIAPHRAGM.
How is pus under the diaphragm explored?
Aka subphrenic abscess: investigated by USS.
How may diverticular disease lead to colonic obstruction? (x2)
Inflammation can lead to narrowing of bowel lumen leading to obstruction, OR a stricture can form from fibrosis arising because of recurrent inflammation.
What are the symptoms of diverticular disease? Asymptomatic? (x5, x2, x3)
o 80-90% are asymptomatic. Remember, diverticulosis is defined as ASYMPTOMATIC. Symptoms are associated with complications
o Diverticular disease: altered bowel habit (diarrhoea OR constipation), left iliac fossa or lower abdominal pain, nausea, flatulence, PR bleed.
o Diverticulitis: same features as diverticular disease + fever.
o Diverticular fistulation into bladder: pneumaturia, faecaluria, recurrent UTI.
How is pain relieved in diverticular disease?
Defecation.