Diuretics part 4

Question 1

What is the mechanism of action of the osmotic diuretic Mannitol?

Answer 1

• filtered by glomerulus
• minimal tubular reabsorption
• no effect on cells
• inhibits passive reabsorption of water
• more medication if more diuresis is desired
• no effect on K+ or other electrolytes

Question 2

What are the therapeutic uses of osmotic diuretic Mannitol?

Answer 2

• can prevent renal failure (by pulling water into the nephron)
• reduces intracranial pressure (draws fluid from brain into the blood)
• reduces intraocular pressure (draws ocular fluid into the blood)

Question 3

What are the adverse effects of the osmotic diuretic Mannitol?

Answer 3

-edema (can exacerbate CHF and pulmonary edema)