Diuretics part 3

Question 1

What diuretics might a potassium sparing (aka spironolactone(Aldactone)) be given with and why?

Answer 1

thiazide or loop to counteract the K+ loss

Question 2

What are the 2 sub categories of potassium sparing diuretics?

Answer 2

aldosterone antagonist

nonaldosterone antagonists

Question 3

What is the prototype for potassium sparing diuretics?

Answer 3

spironolactone (Aldactone)

Question 4

What is the mechanism of action of potassium sparing?

Answer 4

• retains potassium and excretes sodium
• happens in the distal nephron and by then not much diuresis is happening
• takes 1 to 2 days to show effects

Question 5

What are the adverse effects of potassium sparing diuretics?

Answer 5

• hyperkalemia
• endocrine problems (it is a steroid derivative)
• benign and malignant tumors (given long term)

Question 6

What are the therapeutic uses of K+ sparing diuretics?

Answer 6

• hypertension and edema
• heart failure
• women problems

Question 7

Drug interaction:

What is spironolactone (Aldactone) often given with?

Answer 7

loop or thiazide diuretics

-to counteract the K+ wasting effects

Question 8

What are the drug interactions for spironolactone (Aldactone)?

Answer 8

-watch when pt is taking K+ supplement, salt substitutes, or another K+ sparing diuretic