Diuretics Flashcards
1
Q
Thiazides
Spironolactone
A
Like Gitleman syndrome Inhibit Sod. And cloride reab (sod cloride symporter on luminal membrane cotransport)in distal tubule , And decrease osmotic absorption of water, enhancing sodium delivery to collecting dust facilitating k loss and inhibit active exchange of Cl-Na in cortical diluting ascending limb of loop of Henle)so hypo/ kalemia :magnesemia/ natremia so (DI)//::Gout)/ enhancing ca reabsorption so hypercalcemia and hypokalemic metabolic alkalosis
Pot sparring/ ( aldosterone sensitive Na channel) aldost antagonist at distal tubule/ spironolactone/ hyponatremia/ gynecomastia/ impotence
Loop as Barter syndrome: exchange of 2Cl-Na-k) in thick ascending loop of Henle
