Barter Syndrome

Question 1

Barter syndrome
Defect, clinically
Ttt

Answer 1

Thick Ascending loop of henle
Hypokalemia, hypocholremia, metabolic alkalosis, hypereninemia, and hyperaldosteronism
In new born : polyhydramnios FTT
Ttt: spironolactone(blocks distal tubule sodium-potassium exchange ) potassium, indomethacin

Question 2

Explain defect of barter

Answer 2

Sodium chloride reabsorption without water in the loop of Henle creates the medullary concentration gradient required for excretion of maximally concentrated urine in the presence of ADH. The impaired concentrating ability and polyuria due to impaired sodium chloride reabsorption in the medullary thick ascending limb of the loop of Henle in Bartter leads to volume depletion leads to leads to secondary hyperaldosteronism abd with increased distal flow delivery of sodium, results in increased urinary potassium losses and hydrogen ion secretion. paracellular reabsorption of both calcium and magnesium in the thick ascending limb requires the electrochemical gradient created by sodium chloride transport in this tubule segment. Thus, abnormal sodium chloride transport in the thick ascending limb increases renal calcium and magnesium excretion.

Question 3

Loop of Henley

Answer 3

D