Diuretics

Question 1

Furosemide Class

Answer 1

Loop Diuretic

Question 2

Furosemide MOA

Answer 2

Inhibits reabsorption of Na, Cl, K and Mag in the thick ascending loop of Henle

Question 3

Furosemide Uses (5)

Answer 3

Treatment

• Hypertension
• Heart failure
• Peripheral and pulmonary edema
• Increased ICP
• Renal failure

Question 4

Furosemide Dosing

Answer 4

Start with 5 mg and titrate up as needed

Can range from 20-80mg IV not to exceed 200mg/dose

Question 5

Furosemide Onset and DOA

Answer 5

Onset: 5 minutes
DOA: 2 hours

Question 6

Furosemide Metabolism

Answer 6

Liver

Question 7

Furosemide Excretion

Answer 7

Kidneys

Question 8

Furosemide Admin Considerations (5)

Answer 8

Hypotension

Electrolyte abnormalities (decrease K, Mg and Cl levels)

Ototoxic (tinnitus)

Potentiates neuromuscular blockers

Can have hypersensitivity reaction

Question 9

Mannitol Class

Answer 9

Osmotic diuretic

Question 10

Mannitol MOA

Answer 10

Increases serum osmolarity, decreases reabsorption of water, increases excretion of Na+, CL- , and bicarb which induces osmotic diuresis

Helps pull fluid away from brain

Question 11

Mannitol Uses (2)

Answer 11

Treats
-Increased ICP

Improve renal perfusion

Question 12

Mannitol Dosing

Answer 12

0.25-1 g/kg over 30-60 mins

Question 13

Mannitol Onset and DOA

Answer 13

Onset: 15 minutes
DOA: 3-6 hours

Question 14

Mannitol Metabolism

Answer 14

Not metabolized

Question 15

Mannitol Excretion

Answer 15

Kidneys (100% unchanged)

Question 16

Mannitol Admin Considerations

Answer 16

Risk for hypovolemia, electrolyte abnormalities, pulmonary edema