Beta Antagonists Flashcards

1
Q

Labetalol Class

A

Non-selective beta antagonist

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2
Q

Labetalol MOA (3)

A

Competitive antagonist of β1, β2 and α1 receptors

Decreases SVR. BP, and HR

β-blockade: α-blockade ratio is 7:1

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3
Q

Labetalol Use (2)

A

Used to treat tachycardia and hypertension

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4
Q

Labetalol Dosing

A

Intermittent boluses: 5 – 20 mg

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5
Q

Labetalol Onset and DOA

A

Onset: 5 minutes
DOA: 3-6 hours

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6
Q

Labetalol Metabolism

A

Liver

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7
Q

Labetalol Excretion

A

Liver and Kidneys

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8
Q

Labetalol Admin Considerations (3)

A

Caution in patients with bradycardia, hypotension, CHF, asthma and COPD

May cause left ventricular failure, orthostatic hypotension, and bronchospasm

No reflex tachycardia

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9
Q

Esmolol Class

A

Selective β1 antagonist

Class II antiarrhythmic

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10
Q

Esmolol MOA

A

Competitive antagonist of β1 receptors (inhibit β2 receptors at higher doses)

Slows conduction of AV node -> decreases HR & BP

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11
Q

Esmolol Uses (2)

A

Used to prevent or minimize tachycardia and hypertension in response to perioperative stimuli, such as intubation, surgical stimulation, and emergence

May decrease post operative opioid requirements

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12
Q

Esmolol Dosing

A

Bolus: 0.5 mg/kg or 10 mg

Infusion: 50-300 mcg/kg/min)

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13
Q

Esmolol Onset and DOA

A

Onset: 1 minutes
DOA: 5-10 minutes

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14
Q

Esmolol Metabolism

A

Rapid hydrolysis by plasma esterase metabolism in RBCs

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15
Q

Esmolol Excretion

A

Kidneys

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16
Q

Esmolol Admin Consideration

A

Caution in patients with bradycardia, hypotension, CHF, bronchoconstriction, and high degree AVB