ND-NMBA Drugs Flashcards
Rocuronium Class
Steroidal nondepolarizing muscle blocking agent
Rocuronium Use
Standard and rapid sequence induction
Maintenance of neuromuscular blockade
Rocuronium Dosing
Induction dosing: 0.6 – 1.2 mg/kg
RSI dose: 1.2 mg/kg
Rocuronium Onset and DOA
Onset: 3 minutes
DOA: 60 minutes
Rocuronium Metabolism
Hepatic and renal
Rocuronium Excretion
Eliminated by the liver (20%) and kidneys (80%)
Rocuronium Reversal
May reverse with sugammadex
Vecuronium Class
Steroidal nondepolarizing muscle blocking agent
Vecuronium Use
Standard induction and maintenance of neuromuscular blockade
Vecuronium Dosing
Induction dosing: 0.1 mg/kg
Vecuronium Onset and DOA
Onset: 4 minutes
DOA: 60 minutes
Vecuronium Metabolism
Hepatic and renal
Vecuronium Excretion
Eliminated by the liver (50%) and kidneys (50%)
Vecuronium Reversal and Considerations
May reverse with sugammadex
Must be reconstituted
Cisatracurium Class
Benzylisoquinolinium nondepolarizing muscle blocking agent
Cisatracurium Use
Standard induction and maintenance of neuromuscular blockade
Cisatracurium Dose
Induction dosing: 0.1 mg/kg
Cisatracurium Onset and DOA
Onset: 4 minutes
DOA: 60 minutes
Cisatracurium Metabolism
Hofmann elimination (75%) and nonspecific esterase hydrolysis (25%)
Cisatracurium Active Metabolite
Laudanosine metabolite, which is a CNS stimulant
20% less laudanosine is produced when compared to atracurium
Cisatracurium Excretion
Eliminated by the kidneys
Cisatracurium Special Considerations
Hofmann elimination is a temperature- and pH-dependent break- down of the drug molecule.
