Disorders of the Liver and Pancreas Heptobilary Flashcards
Liver
“Metabolic factory” of the body
- Largest internal organ in the body; essential for life
- Functions in the manufacture, storage, transformation, and excretion of many substances involved in metabolism, production of plasma proteins and clotting factors, Breakdown of old and damaged erythrocytes, Bile production
-Receives blood from hepatic portal vein
Transport of nutrients from intestine to liver
-Hepatocytes store nutrients
Play role in carbohydrate, protein, fat metabolism
Pancreas
Exocrine (contributes to digestion) and endocrine functions (insulin, glycagon, somatostatin, and pancreatic polypeptide)
Secretes digestive enzymes, electrolytes Trypsin Chymotrypsin Carboxypeptidase Ribonuclease Pancreatic amylase Bicarbonate ions
Pancreatic duct joins bile duct to enter duodenum
slide 6 has manifesations of liver disease
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Prehepatic jaundice
Result of excessive destruction of red blood cells
Characteristic of hemolytic anemias or transfusion reactions
Unconjugated bilirubin level elevated
Intrahepatic jaundice
Occurs with disease or damage to hepatocytes
Hepatitis or cirrhosis
Both unconjugated and conjugated bilirubin levels may be elevated.
Posthepatic jaundice
Caused by obstruction of bile flow into gallbladder or duodenum
Tumor, cholelithiasis
Increased conjugated bilirubin level
Light-colored stool caused by absence of bile
Bilirubin Measurement in Jaundice
Direct or conjugated bilirubin can be measured in the blood.
Total bilirubin is measured in blood.
Indirect or unconjugated bilirubin = total bilirubin minus direct bilirubin
Cirrhosis
Progressive destruction of the liver – leads to cellular death when 80 – 90% f the liver has been destroyed
Damaged liver regenerate as fibrotic areas instead of functional cells, causing lymph damage and alterations in live restructure, function and blood circulation
Extensive diffuse fibrosis
Interferes with blood supply
Bile may back up.
Loss of lobular organization
Degenerative changes may be asymptomatic until disease is well advanced.
Liver biopsy and serologic test to determine cause and extent of damage
Causes of cirrhosis
-Alcoholic liver disease (15%)
-Biliary cirrhosis
Associated with immune disorders
-Postnecrotic cirrhosis
Linked with chronic hepatitis (26% Hep C, 15% Hep B) or long-term exposure to toxic materials
-Metabolic
Usually caused by genetic metabolic storage disorders
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Functional Losses with Cirrhosis
Decreased removal and conjugation of bilirubin
Decreased production of bile
Impaired digestion and absorption of nutrients
Decreased production of blood-clotting factors (Prothrombin/Fibrogen) & plasma Proteins (albumin)
Impaired glucose and glycogen metabolism
Impaired conversion of ammonia to urea
Inadequate storage of iron and vitamin B12
Congestion in intestinal walls and stomach
Impairing digestion and absorption
Development of esophageal varices **next slide
Hemorrhage
Development of ascites, an accumulation of fluid in the peritoneal cavity **following 2 slides
Causes abdominal distention and pressure
Decreased inactivation of hormones and drugs- Drug dosages must be carefully monitored to avoid toxicity.
Decreased removal of toxic substances (ammonia & drugs)
Reduction of bile entering the intestine- Impairs digestion and absorption
Backup of bile in the liver- Leads to obstructive jaundice
Blockage of blood flow through the liver- Leads to portal hypertension
Congestion in the spleen- Increases hemolysis
Cirrhosis: Subjective Data
- Personality changes, forgetfulness, disorientation
- Fatigue, drowsiness, mild tremors, or flue-like sx
- Gynecomastia, ab distention & measure abd girth
Initial manifestations often mild and vague
of cirrhosis
Fatigue, anorexia, weight loss, anemia, diarrhea
Dull aching pain may be present in upper right abdominal quadrant.
Advanced cirrhosis
Ascites and peripheral edema
Increased bruising
Esophageal varices (May rupture, leading to hemorrhage, circulatory shock)
Jaundice, encephalopathy
Cirrhosis: Treatment
Avoidance of alcohol or specific cause
Avoid fatigue
Avoid exposure to infection
Supportive or symptomatic treatment
Dietary restrictions (high carbohydrate intake and vitamin supplements, restrict protein, fat, & Na++)
Balancing serum electrolytes (possibly diuretics)
Paracentesis
Antibiotics to reduce intestinal flora (neomycin)
Cirrhosis: Treatment
-Esophageal and gastric varice:
Long-term management
Shunting procedures
Monitor for hypovolemia & bleeding
- Drug therapy Vitamin K blood clotting
- Emergency treatment if esophageal varices rupture
- Liver transplantation (suitable living donor = liver tissue is able to grow in both donner and recipient providing a complete functional liver for both)
Hepatitis
Inflammation of the liver results in degeneration and necrosis.
Mild inflammation impairs hepatocyte function.
More severe inflammation and necrosis may lead to obstruction of blood & bile flow
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Alcoholic (Fatty liver) Idiopathic (Fatty liver) Viral hepatitis (Local infection) Infection elsewhere in body(infectious mononucleosis or amebiasis) Chemical or drug toxicity
Viral Hepatitis
Cell injury results in inflammation and necrosis in the liver.
-Degrees of inflammation and damage vary.
Liver is edematous and tender.
Causative viruses
Hepatitis A virus (HAV) Hepatitis B virus (HBV) Hepatitis C virus (HCV) Hepatitis D virus (HDV) Hepatitis E virus (HEV)
*Hepatitis A (HAV)
know mainly abc and how they are transmitted
o Small RNA virus
o Infectious hepatitis
o Transmitted by fecal-oral route in areas of inadequate sanitation or hygiene
–Often from contaminated water or shellfish
o Sexual transmission has occurred during anal intercourse.
o Acute but self-limiting infection
o No carrier or chronic state
o Fecal shedding of virus before onset of signs
o Vaccine available for travelers, food care workers, and health care workers