Disease of Skeletal Muscles Flashcards
where are the nuclei found in skeletal muscle
peripherally
neurogenic disease?
no necrosis or rengeration or fibrosis(except in eldery patients)
there is an increase in nuclei
myopathic disease
- central nuclei
- necrosis, regeneration, and sometimes fibrosis, inflamation
distrophin is important for what
contraction
what is Duchenne Muscular Dystrophy
Duchenne muscular dystrophy is an inherited disorder that involves muscle weakness, which quickly gets worse.
what is caused by the defective gene of distrophin
Duchenne muscular dystrophy
Duchenne muscular dystrophy usually affects..
boys
in duchenne muscular dystrophy one will be wheel chair dependent when
age 12
when is distrophin present but abnormally short due to in frame deletions
becker muscular dystrophy
what is the inherited disorder that involves slowly worsening muscle weakness of the legs and pelvis.
becker muscular dystrophy
What problem includes at least 18 different inherited disorders, which first affect the muscles around the shoulder girdle and hips. These diseases get worse, and may eventually involve other muscles.
Limb girdle muscular dystrophy
what refers to a muscular dystrophy that is caused by mutations in the dysferlin gene regardless of the clinical presentation.
dysferlinopathy
what will provide the early inability to tip toe
Dysferlinopathy
What causes muscle weakness, usually in the muscles closest to the trunk of your body.
polymyositis
what causes muscle weakness, plus a skin rash
dermatomyositis
