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Reproductive > Disease Of Ovaries > Flashcards

Disease Of Ovaries Flashcards

1
Q

Disease of the ovaries

A

Follicular cysts

Tumors

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2
Q

Follicular cysts single or multiple ?

A

Both

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3
Q

Single cysts presentation

A

Large and associated with amenorrhea

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4
Q

Multiple cysts presentation

A

Smal and associated with endometrial hyperplasia

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5
Q

Type of follicles that lead to follicular cysts

A

Graffian follicle

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6
Q

Cells that line follicular cysts

A

Granulosa cells

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7
Q

Theca lutein cysts surrounded by

A

Luteinised granulosa cells

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8
Q

Pcos type of cysts

A

Bilateral multiple small cysts

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9
Q

Stein leventhal syndrome see in PCOS characteristics

A

Obesity
Hirsutism
Oligomenorrhea

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10
Q

What are chocolate cyst

A

Ovarian endometriosis cysts

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11
Q

Working classification of ovarian tumors

A 
Epithelial tumors 
Sex cord/ stromal tumors 
Germ cell tumors
Others 
Secondary metastatic tumors
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12
Q

2 types of epithelial tumors of ovary

A

Mature mullerian tissue

Analogous tumors

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13
Q

Epithelial tumors of Mature mullerian tissues types

A

Tubal epithelium
Endocervical epithelium
Endometrial epithelium
Transitional epithelium

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14
Q

Analogous tumors types

A

Serous
Mucinous
Endometriod
Brenners

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15
Q

3 types of tumors

A

Benign
Border line
Malignant

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16
Q

Benign tumors characteristics

A

Acini lined by single cell layer

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17
Q

Borderline tumors characteristics

A

Epithelium heaped up
Moderate nuclear atypia and mitoses
No stromal invasion

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18
Q

Malignant tumor characteristics

A

Solid epithelium
Moderate to severe atypia
Stromal invasion

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19
Q

Percentage of surface epithelial tumor in ovarian tumor

A

65-70%

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20
Q

Percentage of surface epithelial tumor of malignant tumor

A

90%

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21
Q

Age group surface epithelial tumor

A

More than 20yo

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22
Q

Ovarian ca concerns developed or developing societies

A

Developed

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23
Q

H what offers protection against surface epithelial tumors

A

OCP

Pregnancy

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24
Q

Risk factor

A

Talc to vulva
Trauma to surface epithelium
Family history (5x more sisters and mothers)

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25
Q

Percentage of hereditary ovaria ca

A

5%

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26
Q

Mutation leading to ovarian ca

A

P53 pt mutation

If erbB-2 (her-2/neu ) on top , poor prognosis

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27
Q

Gynecological malignancy with the most death

A

Ovarian carcinoma

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28
Q

Form of spread of ovarian tumor

A

predominantly intra-abdominal

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29
Q

Ciara marker of ovarian cancer

A

CA125

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30
Q

Serous cystadenoma ovarian tumor percentage

A

25

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31
Q

Morphology Serous cystadenoma

A

Cuboidal lining epithelium
Few Intracystic papillary projection
Watery fluid

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32
Q

Is malignant transformation common in Serous cystadenoma

A

Yes

33
Q

Commonest malignant tumor of the ovary

A

Serous cystadenocarcinoma

34
Q

Percentage of Serous cystadenocarcinoma out of Malignant tumors of ovary

A

60

35
Q

Morphology of Serous cystadenocarcinoma

A

Exuberant papillomatosis Groves over surface of ovary which obliterate ovarian structure

36
Q

D percentage mucinous cystadenoma

A

20% of all ovarian tumors

37
Q

Morphology of mucinous cystadenoma

A

Multilocular pattern
Tall columnar epithelium
Gelatinous secretion

38
Q

Type of tumor that can rupture and cause pseudomyxoma peritonei due to mucus secreting epithelium on the peritoneum

A

mucinous cystadenoma

39
Q

mucinous cystadenocarcinoma % in all carcinoma of ovary

A

20

40
Q

Morphology of mucinous cystadenocarcinoma

A

Florid papillary pattern in malignant areas

41
Q

Percentage brenners tumor in ovarian tumor

A

2%

42
Q

Brenners tumor morphology

A

Fibroblastic stroma
Island of transitional epithelium
Mucinous meta0lasia
Stromal calcification and cysts

43
Q

What is Endometrioid carcinoma

A

Solid or semisolid tumor

Mostly arising from surface epithelium of millenarian metaplasia along endometrial lines

44
Q

Is there a benign counterpart to Endometrioid carcinoma

A

No

45
Q

Two groups of sex cord and stromal tumor

A

Estrogen producing

Androgen producing

46
Q

Estrogen producing tumor

A

Granulosa cell tumor

Thecomas or fibromas

47
Q

Androgen producing cell

A

Sertoli Leydig cell tumors
Hilus cell tumor
Lipid cell tumor

48
Q

Type of cll in Granulosa cell tumor

A

Cell resembling Granulosa cells

49
Q

Percentage of Granulosa cell tumor

A

2% of ovarian tumor

50
Q

Morphology of Granulosa cell tumor

A 
Micro follicle (call exner bodies)
Coffee beans cells
51
Q

Hormone excessively produced in Granulosa cell tumor

A

Estrogen

52
Q

What are Thecomas

A

Tumor of ovarian mesenchyme

53
Q

Morphology Thecomas

A

Unilateral Firm solid

54
Q

Consequences of estrogen production

A

Precocious puberty
Endometrial hyperplasia
Enlargement of breast
Post menopausal bleeding

55
Q

Main association to fibromas

A

Meigs syndrome wirh peritoneal and pleural effusion

56
Q

Tumor that typifies virilising tumor group

A

Sertoli-Leydig cell tumor

57
Q

Sertoli-Leydig cell tumor macro morphology

A

Small Yellow in ovary

58
Q

Sertoli-Leydig cell tumor micro morphology

A

Tubule line day Sertoli cell

Leydig cell in stroma like testes

59
Q

Androgen release consequences

A 
Atrophy of  testes 
External genitalia atrophy
Voice deepening 
Facial and body hair growth 
Clitoris enlargement
60
Q

Different ways germ cell tumor can différente

A

Primitive cell - dysgerminoma
Embryonic differentiation- Teratoma
Extra embryonic differentiation - yolk sac tumor , choriocarcinoma

61
Q

What are dysgerminoma

A

Malignant

Solid tumor

62
Q

dysgerminoma morpho

A

Large round cell with large nuclei resembling germ cells
Alveoli pattern
Fine connective tissue

63
Q

Teratomas type

A

Mature and immature

Cystic or solid

64
Q

Cystic Teratoma

A 
Common tumor of ovary 
All ages 
Unilocular 
Eminence of one part with hair 
stratified squamous epithelium which can become malignant
65
Q

Solid teratoma characteristics

A

Solid
Unilateral
Large
rare

66
Q

What is monoplyetic Teratoa

A

One type of tissue
Stroma ovarii is thyroid tissue
Carcinoid tumor seen in ovary

67
Q

Highly malignant tumor of women under 30yo

A

Yolk sac tumor

68
Q

Histology of yolk sac tumor

A

Resemble mesenchyme of primitive yolk sac

69
Q

Second most common malignant germ cell tumor

A

Yolk sac tumor

70
Q

Morphology of yolk sac tumor

A

Large
extensive necrosis and hemorrhage

Reticular honeycombed structure of communicating species lined by primitive cells
Schiller duval bodies

71
Q

Regarde are Schiller duval bodies

A

Papillae that protrudes into space lined by tumor cells and contai; fibrovascular core

72
Q

Protein secreted by yolk sac tumor

A

A-fetoprotein seen I pin eosinophilic droplets

73
Q

Prognosis for yolk sac tumor

A

Good nowadays due to chemotherapy

Exceed 80% 5ysr

74
Q

Staging of ovarian cancer

A
75
Q

What is choriocarcinoma

A

Secretes hcg highly metastatic

Similar to gestational choriocarcinoma

76
Q

Secondary tumor of ovaries which is Adenocarcinoma from stomach or large intestine

A

Krukenberg tumor

77
Q

Characteristics of krukenberg tumor

A

Mucous secretion
Signet ring cell
Bilateral

78
Q

Lymphomas of the ovaries, primary or secondary

A

Both

79
Q

Burkitt lymphoma of ovaries primary or secondary

A

Primary

Reproductive (14 decks)

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