Disease of Adrenal Cortex Flashcards
1
Q
- destruction of adrenal gland (Addisions’ disease)
- lack of ACTH (secondary)
- autoimmune destruction of adrenal gland
A
adrenal insufficiency
2
Q
- nonselective inhibitor of adrenal and gonadal steroids
- can cause headaches, sedation, nausea
- potential hepatotoxicity
A
ketoconazole
3
Q
- nonselective cytotoxic agent on adrenal cortex
- reserved for patients with adrenal carcinoma
- d/n/v,depression
A
mitotane toxicity
4
Q
- glucocorticoid receptor antagonist
- rapidly effective for diabetes related to Cushings
- QT prolongation, hypokalemia
A
mifepristone
5
Q
- asymptomatic hypertension, unprovoked hypokalemia
- hypokalmeic alkalosis
- edema
- results from autonomous renin angiotensin independent disorder of zona glomerulosa
A
primary hyperaldosteronism
6
Q
- hypertension, hypokalemia, increased aldosterone and plasma renin activity
- renal artery stenosis
A
secondary hyperaldosteronism
7
Q
- mineralocorticoid antagonists, reverse effects of aldosterone
- limits potassium loss, benefits HTN
A
spironolactone and eplerenone
8
Q
- AR disorders, deficiency of an enzyme required for synthesis of cortisol in adrenal cortex
- mostly 21hydroxylase deficiency, full or partial block of mineralocorticoid production, spillover into androgen path
A
congenital adrenal insufficiency
9
Q
- abiguous genitalia in females with large clitoris, partly fused labia majora, common urogenital sinus
- boys: no overt sign, hyperpigmentation
- untreated: rapid somatic grwoth, advanced bone age, premature epihphyseal fusion, acne
- tx: glucocorticoids
A
21 OH deficiency
10
Q
- ambiguous genitalia in females with large clitoris, partly fused labia majora, common urogenital sinus
- boys: no overt sign, hyperpigmentation
- untreated: rapid somatic growth, advanced bone age, premature epiphyseal fusion, acne
- tx: glucocorticoids
A
21 OH deficiency
