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1 STEP General pharm (UW ir FA) > direct sympatomimetics > Flashcards

direct sympatomimetics Flashcards

1
Q

midodrine receptors?

A

alpha 1

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2
Q

NE receptors?

A

alpha1>alpha2>beta1

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3
Q

phenylephrine receptors?

A

alpha1>alpha2

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4
Q

which drug acts only on alpha1?

A

midodrine

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5
Q

which drug acts on alpha1>alpha2»beta1?

A

NE

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6
Q

which drug acts on alpha1>alpha2?

A

phenylephrine

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7
Q

midodrine used for?

A

autonomic insufficiency and postural (orthostatic) hypotension

may exacerbate supine hypertension

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8
Q

NE used for?

A

hypotension, septic shock

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9
Q

Phenylephrine used for?

A

hypotension, ocular procedures (mydriatic), rhinitis (decongestant), ischemic priapism

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10
Q

midodrine hemodynamic changes?

A

incr. BP (vasoconstrictor), decr. HR, -/decr CO

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11
Q

NE hemodynamic changes?

A

incr. BP (vasoconstrictor), -/decr. HR (may occur reflective decr. in HR due to incr. BP due to alpha 1 agonism outweighting direct B1 chronotropic effect), -/ increased CO

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12
Q

phenylephrine hemodynamic changes?

A

incr. BP (vasoconstriction), decr. HR, -/decr. CO

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13
Q

isoproterenol receptors?

A

beta1=beta2

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14
Q

what drug acts beta1=beta2?

A

isoproterenol

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15
Q

isoproterenol used for?

A

electrophysiologic evaluation of tachyarrhytmias. can worsen ischemia

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16
Q

isoproterenol hemodynamic changes?

A

decr. BP (vasodilation), incr. HR and incr. CO

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17
Q

dobutamine receptors?

A

beta1>beta2>alpha1

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18
Q

beta1>beta2>alpha1 what drug?

A

dobutamine

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19
Q

dobutamine used for?

A

cardiac stress testing, congestive HF with cardiogenic chock (inotrope)

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20
Q

cardiac stress testing, congestive HF with cardiogenic chock (inotrope) what drug?

A

dobutamine

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21
Q

dobutamine hemodynamics?

A

-/decr. BP
incr. HR,
incr CO

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22
Q

fenoldopam receptors?

A

D1

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23
Q

D1 receptor agonist?

A

fenoldopam

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24
Q

fenoldopam elimination 1/2?

A

5 min

25
Q

fenoldopam application?

A

postoperative hypertension, hypertensive crisis
vasodilator (renal, coronary, splanchnic, peripheral)
promotes natriuresis
can cause hypotension and tachycardia

26
Q

which drug promotes natriuresis?

A

fenoldopam

27
Q

vasodilator (renal, coronary, splanchnic, peripheral)?

A

fenoldopam

28
Q

postoperative hypertension, hypertensive crisis?

A

fenoldopam

29
Q

fenoldopam hemodynamic?

A

decr. BP, incr. HR, incr. CO

30
Q

dopamine receptors?

A

D1=D2>beta?alpha

31
Q

D1=D2>beta1>alpha1; drug?

A

dopamine

32
Q

dopamine application?

A

unstable bradycardia, HF, shock

33
Q

dopamine low doses receptors?

A

D1

34
Q

dopamine medium doses receptors?

A

beta1

35
Q

dopamine high doses receptors?

A

alpha1

36
Q

what effects on heart are due to dopamine?

A

inotropic and chronotropic at lower doses due to beta1

37
Q

what effects on vessels are due to dopamine?

A

vasoconstriction at high doses due to alpha effects

38
Q

dopamine hemodynamics?

A

incr. BP (high doses due to vasoconstriction); incr. HR, incr. CO

39
Q

mirabegron receptor?

A

beta3

40
Q

beta3 rec. drug?

A

mirabegron

41
Q

mirabegron application?

A

urinary urgency in incontinence or overreactive bladder.

42
Q

urinary urgency in incontinence or overreactive bladder drug?

A

mirabegron

43
Q

mirabegron hemodynamic?

A

none

44
Q

albuterol, salmeterol, terbutaline receptors?

A

beta2>beta1

45
Q

beta2>beta1 drugs?

A

albuterol, salmeterol, terbutaline

46
Q

albuterol application?

A

ACUTE asthma/COPD.

47
Q

salmeterol application?

A

long term asthma/COPD.

48
Q

terbutaline application?

A

acute bronchospasm and tocolysis (premature labor supression)

49
Q

drug for tocolysis?

A

terbutaline

50
Q

albuterol, salmeterol, terbutaline hemodynamics?

A

little increase in HR

51
Q

epinephrine receptors?

A

beta>alpha

52
Q

beta>alpha drug?

A

epinephrine

53
Q

epinephrine application?

A

anaphylaxis, asthma, open-angle glaucoma;
alpha predominate at high doses;
stronger effect on beta2 than NE

54
Q

anaphylaxis, asthma, open-angle glaucoma;
alpha predominate at high doses
drug?

A

epinephrine

55
Q

epinephrine. Low dose receptors?

A

beta1, beta2

56
Q

epinephrine. medium dose receptors?

A

beta1; beta2 and alpha1 vienas kita kompensuoja

57
Q

epinephrine. high dose receptors?

A

alpha1, beta1, beta2 - alpha1 overcomes beta2 effect

58
Q

epinephrine hemodynamics?

A

incr BP (high doses), incr HR, incr CO

1 STEP General pharm (UW ir FA) (7 decks)

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