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1 STEP General pharm (UW ir FA) > cholinomimetics > Flashcards

cholinomimetics Flashcards

1
Q

Betanechol. direct or indirect?

A

direct

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2
Q

Carbachol. direct or indirect?

A

direct

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3
Q

Metacholine. direct or indirect?

A

direct

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4
Q

Pilocarpine. direct or indirect?

A

direct

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5
Q

Donepezil. direct or indirect?

A

indirect

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6
Q

rivastigmine. direct or indirect?

A

indirect

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7
Q

galantamine. direct or indirect?

A

indirect

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8
Q

edrophonium. direct or indirect?

A

indirect

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9
Q

neostigmine. direct or indirect?

A

indirect

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10
Q

physostigmine. direct or indirect?

A

indirect

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11
Q

pyridostigmine. direct or indirect?

A

indirect

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12
Q

Donepezil/rivastigmine/galantamine. CNS?

A

cross BBB

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13
Q

Edrophonium. CNS?

A

does not cross BBB

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14
Q

Neostigmine. CNS?

A

does not cross BBB

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15
Q

Physostigmine. CNS?

A

cross BBB

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16
Q

Pyridostigmine. CNS?

A

does not cross BBB

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17
Q

Betanechol. What receptors?

A

only M (all)

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18
Q

Carbachol. Whart receptors?

A

M and N

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19
Q

Metacholine. what receptors?

A

M>N

20
Q

Pilocarpine. what receptors?

A

M

21
Q

Acetylcholine. direct or indirect?

A

direct

22
Q

Acetylcholine. what receptors?

A

both M and N

23
Q

What for Alzheimer 1st line?

A

Donepezil/rivastigmine/galantamine

24
Q

Postoperative and neurogenic ileus and urinary retention?

A

Neostigmine

25
Q

Myastenia gravis. more often and less often?

A

more often pyridostigmine
less often neostigmine

26
Q

NMJ reversal?

A

neostigmine

27
Q

Antidote for anticholinergic toxicity (atropine)?

A

Physostigmine

28
Q

Which drug induces muscle strenght?

A

pyridostigmine

29
Q

which drug used with glycopyrolate/hyoscyamine/propantheline to control effect?

A

pyridostigmine

30
Q

what is tertiary amines (lipophilic)?

A

cross BBB

31
Q

what is quaternary amines (hydrophilic)?

A

does not cross BBB

32
Q

tertiary - reverse both central and peripheral
quaternary - reverse only peripheral

A

.

33
Q

Which drug stimulates M receptors in airways when inhaled?

A

metacholine

34
Q

metacholine application?

A

chalenge test for diagnosis of asthma

35
Q

which drug ,,copy of ACh”, but resistant to AChE?

A

Carbachol

36
Q

Carbachol application?

A

constricts pupil and relieves intraocular pressure in open-angle glaucoma

37
Q

chalenge test for diagnosis of asthma?

A

metacholine

38
Q

constricts pupil and relieves intraocular pressure in open-angle glaucoma?

A

Carbachol

39
Q

Which durg (direct) artivates bladder and bowel smooth muscles?

A

betanechol

40
Q

betanechol application?

A

urinary retention;
ileus (post-op/neurologic).

41
Q

urinary retention;
ileus (post-op/neurologic)
What drug?

A

direct - betanechol
indirect - neostigmine

42
Q

potent stimulator of sweat/tears/saliva?

A

pilocarpine

43
Q

contracts ciliary muscle –> used in open-angle glaucoma)?

A

pilocarpine

44
Q

contracts sphincter muscle –> used in closed-angle glaucoma)?

A

pilocarpine

45
Q

which direct drug cross BBB (tertiary amine)?

A

pilocarpine

46
Q

which drug used in xerostomia (sjogren)?

A

pilocarpine

1 STEP General pharm (UW ir FA) (7 decks)

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