Anticholinesterase poisoning

Question 1

what are organophosphates?

Answer 1

parathion, malathion, echothiophate

Question 2

organophosphates how inhibit AChE?

Answer 2

IRREVERSIBLE

Question 3

where used organophosphates?

Answer 3

insecticides, usually seen in farmers

Question 4

what are effects by organophosphates? general

Answer 4

muscarinic, nicotinic, CNS effects

Question 5

organophosphates. muscarinic effect?

Answer 5

DUMBBELSS - diarrhea, urination, miosis, bronchospasm, bradycardia, emesis, lacrimation, sweating, salivation

Question 6

muscarinic effects reversed by?

Answer 6

atropine - a competitive inhibitor
ATROPINE CROSS BBB so can relieve CNS symptoms

Question 7

organophosphates. nicotinic effect?

Answer 7

NMJ blockage (mechanism similar to succinylcholine)

Question 8

nicotinic effect reversed by?

Answer 8

PRALIDOXIME - regenerates AChE if given early.
It quaternary amine - does not cross BBB

Question 9

organophosphates. CNS effects?

Answer 9

respiratory depression (lethal complication), lethargy, seizures, coma