Digestive System 2.1: Bile

Question 1

8 Roles of Acetylcholine

Answer 1

Stimule production de salive aqueuse
Stimule motricité oesophagienne et relaxation sphincters oesophagiens
Stimule relaxation réceptive fundus gastrique (effectuée par NO/VIP)
Stimule péristaltisme gastrique
Stimule sécrétion HCl (cellules pariétales)
Stimule sécrétion pancréatique (relâche CCK)
Stimule contraction vésicule biliaire
Stimule péristaltisme intestinal et colique

Question 2

Ihibition of gastrine release

Answer 2

pH < 3.5

Question 3

Role of Gastrin (2)

Answer 3

stimulation sécrétion HCl (Cellules pariétales), a
ctive motricité estomac

Question 4

Cholécystokinine (CCK) roles (2)

Answer 4

Inhibition vidange gastrique (frein duodénal)
Sécrétion enzymes pancréatiques

Question 5

Motiline role

Answer 5

Stimule contractions gastriques interdigestives

Question 6

Somatostatine Role:

Answer 6

Principale hormone inhibitrice (régulatrice) du système GI

Question 7

What is the main role of Bile?

Answer 7

Important for the breakdown of lipids
participent à formation micelles → which can then be broken down by lipases

Question 8

What is special about sels biliares?

Answer 8

Sels biliares and bilirubin need to be conjugated

Conjugation = more soluble

IF some of them are sent to bile without being conjugated they will be reabsorbed back to the liver to be conjugated

NEVER non conjugated

Question 9

Sels biliaires primaires

Properties and what they are

Answer 9

Forme par foi à partir de cholesterol

Cholate

Chenodeoxycholate

Question 10

What do bacteria in the intestinal tract do?

Answer 10

form acides biliares secondaires
de-conjugate molecules

Question 11

What is cycle entero-hepatique:

Answer 11

Sels biliaires participent à digestion lipides
Ensuite réabsorbés dans iléon et recyclés au foie

95% of the sels biliaires will be reabsorbed in the iléon

Question 12

What kind of diet would lead to high acides biliares?

Answer 12

A diet that is rich in lipids

Question 13

What are the transporters for acides biliares from blood to liver and what kind of acids are these?

Answer 13

**Transporters: **
NTCP and OATP
Type: Conjugated

Question 14

Transporteir qui permet la sécrétion de sels biliaires conjugués dans canalicule biliaire

Answer 14

BSEP

Question 15

What is the role of ASBT?

Answer 15

Réabsorption sels biliaires dans iléon

Question 16

What is the role of the biliary vesicle?

Answer 16

Stores bile when not needed and concentrates it for use when a rich in lipid food is injested

Question 17

What is the danger with bile vesicle concentrating bile?

Answer 17

he stored bile will be concentrated

This is done via the reabsorption of water

There is a danger of perticipating the constituents!!

Because of water loss, the concentration becomes less soluble

precisely: if we have a lot of cholesterol and not a lot of bilirubin or water to keep it soluble → formation of rocks