diagnostics and new biomarkers

Question 1

most popular test for CTD

Answer 1

ANA

Question 2

anti-cardiolipin is for

Answer 2

APS

Question 3

tests for vasculitis

Answer 3

MPO, Anti PR3, GBM

Question 4

22 y/o F pain in DIP in both hands what would you request

Answer 4

consider RA, test for Anti CCP

Question 5

it is an IgM antibody against Fc receptor of IgG

Answer 5

RF

Question 6

confirmatory test for vasculitis

Answer 6

ELISA to confirm what type of ANCA (cytoplasmic or peritoneal)

Question 7

P-ANCA is equivalent to

Answer 7

MPO (myeloperoxidase Antibodies)

Question 8

C-ANCA is equivalent to

Answer 8

proteinase 3

Question 9

patter in MPO

Answer 9

perinuclear

Question 10

pattern in PR3

Answer 10

cytoplasmic pattern

Question 11

px tested positive for both c-ANCA and p-ANCA what would be your diagnosis

Answer 11

Wegener’s Granulomatosis

Question 12

in 20-30% of cases PAN is associated with

Answer 12

Hep B Ag

Question 13

what are the 6 IFA basic patterns

Answer 13

homogenous
speckled
nucleolar
centromere
cytoplasmic
negative

Question 14

there are 2 types of centromere autoantibodies and both are related to

Answer 14

CREST syndrome

Question 15

most homogenous patterns are secondary to

Answer 15

SLE

Question 16

presence of rim like fluorescence in the periphery then it is sure that the antibody is secondary to

Answer 16

anti-dsDNA

Question 17

specific marker for systemic sclerosis/scleroderma

Answer 17

Scl 70

Question 18

in this pattern, there is uniform discrete speckles throughout the nucleus (40-60)
+ MIT

Answer 18

centromere

Question 19

net like mitosis

Answer 19

clumpy nuclear pattern

Question 20

this pattern shows small discrete grains in the center of nucleoli
-dots in mitosis

Answer 20

punctuate nuclear pattern

Question 21

nucleolar pattern

Answer 21

scleroderma

Question 22

fine speckled pattern

Answer 22

sjorgen’s syndrome

Question 23

centromeric

Answer 23

CREST