diagnostic methods of rheumatic disease Flashcards
is CRP or ESR better ?
CRP is unaffected by pregnancy or age whilst ESR is
so CRP
a high specificity oor hiigh seensitivity testt for screeniing purposes ?
high sensitivity for screening
high specificity for confirmation
what autoantibody is very seessnitive for RA ?
anti-ccp
what autoantibody is sensitive for SLE ?
homogenous/speckled ANA
what autoantibodies are specific for SLE ?
anti-dsDNA and antii-Sm
what autoantibody is associateed with sjogrren ?
Anti Ro anti la
what autoantibody is associated with polymyositis ?
Anti Jo-1 and hence have a higher risk of interstitial lung disease
what autoantibody is associated with mixed connective tissue disease ?
U1-RNP
can ANA titre be used for the monitoring of disease activity ?
no
what do anti-dsDNA levels tend to correlate with inn SLE ?
renal disease
what are the auto antibodies present in drug induced lupus and what happens to the complement ?
anti-histones
complement are usually not depleted
what kind of drugs causse drug induced lupus ?
anti-TNF - etanercept
isoniazid
procainamide
oestrogen containing drugs
what are the autoantibodies in systemic sclerosis ?
diffuse - Scl-70
limited - anti-centromere
what arre the autoantibodies in weegners granulomatosiis ?
c-ANCA (PR-3)
what are the autoantibodies in polyarteritis nodosa ?
p-ANCA (MPO)
( microscopic vasculitis too )
