acute liver failure Flashcards

1
Q

what is fulimant hepatic failure ?

A

1- evidence of coagulation abnormality INR of 1.5
2- any degree of mental alterations
3- patient without any cirrhosis
all within a span of less. than 26 weeks

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2
Q

what is the classificationn of fulimant liver failure dependant on ?

A

the number of weeks between the onset of jaundice and encephalopathy

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3
Q

whenn should we suspect fulimannt liver failure ?

A

when there is a sudden and rapid deterioration in

  • jaundice
  • coagulopathy
  • encephalopathy
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4
Q

what are the causes of fulimant liver failure ?

A

1- viral causes such as hepatitis A and E and HBV ( most common cause )
2- drugs such as acetaminophen , mushrooms and aflatoxins
3- ischemic (ecstasy or cocaine)
4- metabolic
5- budd-chiari
6- infiltrative
7- pregnancy

drugs including acetaminophen and toxins

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5
Q

what is the main issue with acute liver failure?

A

multisystem organ failure

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6
Q

what is the main cause of death in fulimant liver failure ?

A

sepsis

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7
Q

what is the ultimate treatment for acute liver failure ?

A

liver transplantation

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8
Q

what drug is given to counteract acetamophine ?

A

N-acetylcysteine

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9
Q

what is the managment for acute liver failure ?

A
general and supportive treatment 
manage cause if possible 
give fluids 
PPI 
antibiotics but never imperical
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10
Q

what are the parameters of infection ?

A

fever
leucocytosis
CRP

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11
Q

what can we give for hepatic encephalopathy ?

A

lactulose

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12
Q

what is the kings college criteria divieded into ?

A

acetaminophen induced ALF or non acetaminophen

non acetamophine induced ALF

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13
Q

what. is the most death lading factor in ALF ?

A

sepsis

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14
Q

what is the most common cause of ALF ?

A

viral hepatitis

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