Diabetes Pathophys Flashcards
how high is A1C in diabetes diagnosis
greater then 6.5
how high is fasting plasma glucose in diabetes diagnosis?
greater than 126 mg/dl
how high is 2 hr plasma gluose during OGTT for diagnosis of diabetes?
greater than 200
a random plasma glucose higher than what is sufficient for diabetes diagnosis?
200 mg/dl
what is OGTT?
oral glucose tolerance test
what is A1c in pre diabetes?
5.7-6.4
what is 2 hr plasma glucose during OGTT in pre diabetes?
140-199
what is free plasma glucose in pre diabetes?
100-125
at what age shoudl diabetes testing begin?
at 45, especially for anyone overweight
if someone has prediabetes, when should they be tested for diabetes?
yearly
name some risk factors for diabates
first degree relative high risk race cardiovascular disease HTN hyperlipidemia obesity
what are high risk races for diabetes?
AA, latine, asian, pacific islander
when should you screen for type 2 diabetes in kids?
overweight with at least one risk factor
in end of type 1 DM, will c peptide be present
NO
what is most common cause of young adult/child diabetes?
type 1 DM
can older adults have type 1 DM?
you betcha
what type of diseases often coincide with type 1 dm?
other autoimmune diseases…hypothyroid most common
what are the three antibodies you can find in type 1 DM?
anti-GAD,
anti-insulin (IAA)
anti0 ICA512 (islet cell antibody)
what is most common co morbid autoimmune disease with type 1 DM?
hashimotos and celiac
what does hyperglycemia in type II DM lead to with fatty acids?
eventually they start to accumulate and levels will rise
what do high free fatty acid levels cause in type II DM?
further inhibition of insulin release
which of type 1 or 2 DM has higher genetic contribution?
type II more common to have genetic component
is ketoacidosis more common in type I or II DM?
type I dm
will C peptide be present in type 2 DM?
yes…
will incretin be increased or decreased in type II DM?
it decreases
will glucagon be icnreased or decreased in type II DM?
increased
will glucose absorption be increased or decreased in type II?
increased
will lipolysis be increased or decreased in type II DM?
increased
