Diabetes Pathology Flashcards
What % of diabetic patients have T1DM?
15%
What is the most common ethnicity of patients with T1DM?
Caucasion
North European
What is the most common age of presentation of T1DM patients?
Puberty
But can be any age
What is the pathophysiology of T1DM?
Gradual destruction of Bcells due to autoimmunity
What is the most common subtype of T1DM?
Type 1A
Immune regulated form
90% have mutations in HLA genes on chromosome 6
Name a non genetic risk factor for T1DM?
Clean environment during childhood with little exposure to pathogens
Name 5 common symptoms of T1DM at presentation?
Polydipsia (increased thirst)
Increased urination (especially at night)
Weight loss/ fatigue
Itching around genitals/ bouts of thrush
Name 3 signs of diabetic patients seen at presentation?
Hyperglycemia
Glucosuria
Ketoneuria?
Name 6 emergency signs in a presentation of T1DM?
Loss of appetite/ N+V
Fever/ drowsy/ confused
Stomach pain
Fruity (pear drop) breath - ketoacidosis
What glucose levels (fasting and random) indicate possible diabetes?
Random glucose >11.1mmol/L
Fasting glucose >7mmol/L
What are the diagnostic criteria for T1DM when doing glucose tests?
ONE random/ fasting glucose out of range if symptomatic
TWO randon/fasting glucose out of range if asymptomatic
What HbA1c level is diagnostic of diabetes?
> 48mmol/L (6.5%)
Although result lower than this does not exclude diagnosis if glucose test disagrees
What is the treatment for T1DM?
Always need insulin!
Education/ healthy diet/ weight loss/ smoking cessation
What are the two different methods of insulin dosing?
Twice Daily: Intermediate insulin (isophane)
- Works within 2hrs, lasts 18-24hrs
Multiple Dose: Rapid acting insulin
- Best for Px with good understanding/ control
Px taking insulin on a multiple dose regimen should take their insulin when?
Before/ with a meal
What is the main type of twice daily insulin?
Hypurin isophane (either bovine or porcrine)
Name the two most common rapid acting insulins?
Novorapid
Humalog (works in 15mins)
Lasts 3-5hrs
What is analouge insulin?
Similar to human but with recominant DNA
Where AA’s have been changed to change insulin properties
What is HbA1c?
A reliable indicator of mean glucose levels over the last 120 days
Why can HbA1c be used to give estimates of glucose?
As glycation (adding of sugar) to the Hb occurs at a variable rate over an RBC’s 120 day lifespan, so proportions of glycated reflect how much sugar has been in the blood
What is the normal level of HbA1c?
4-6% (20-43mmol/L)
Name 8 symptoms of hypoglycemia?
Shaking/ sweating
Weakness/ confusion
Hunger/ tingling lips
Slurred speech/ unconciousness/ transient hemipariesis
How would you treat a hypoglycemic patient when in a hospital?
If mild treat sugary drinks/ food
Give 80ml of 20% glucose IV
How would you treat a hypoglycemic patient when not in a hospital?
If mild give sugary drinks/ food
1mg (1unit) glucagon intramuscular
Name 4 risk factors than can predispose a diabetic patient to have a ‘hypo’:
Exercise
Taking too much insulin
Drinking alcohol on an empty stomach
Skipping meals
What is the clinical definition of hyperglycemia?
Blood glucose >11.1mmol/L
What is the classic triad of symptoms of hyperglycemic Px?
Polyphagia (hunger)
Polydipsia (thirst)
Polyuria (frequent urination)
(Add diabetic symptoms/ dry mouth/ drowsiness)
Prolonged hyperglycemia can lead to (5)?
Diabetic ketoacidosis
Renal/ cardiovascular/ neural/ retina damage
What is the pathophysiology of T2DM?
Disorder of receptors (increased triglyceride levels can cause release of inflam proteins/cytokines which damage 2nd messengers). Hyperinsulinaemia initially compensates but this eventually leads to Bcell damage
What % of patients with DM have T2DM?
90%
What ethnicity is most subceptible to T2DM?
Afrocarribean
Name 7 RF’s for developing T2DM:
‘Central’ obesity/ lack of physical activity
Low fibre, high sugar diet/ metabolic syndrome
Family history/ Polycystic ovary syndrome
Low birth weight/ gestational diabetes