Diabetes mellitus Flashcards

1
Q

If a diabetes drug begins with “Gli-“, what class is it?

A

Sulfonylurea (eg glibenclamide)

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2
Q

What value for a random plasma glucose is diagnostic of diabetes mellitus?

A

> 11.1 mmol/L + symptoms

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2
Q

What do all SGLT2 inhibitor drug names start or end with?

A

End with “-aglifozin”

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3
Q

What is the range for impaired fasting blood glucose?

A

6.1-6.9 mmol/L

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4
Q

If a diabetes drug ends with “-aglifozin”, what class is it?

A

SGLT2 inhibitor

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6
Q

If a diabetes drug ends with “-gliptin”, what class is it?

A

DPP4 inhibitor (inhibits degradation of GLP-1) (eg sitagliptin)

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7
Q

What do all sulfonylurea drugs start or end with?

A

Start with “Gli-“ (eg glibenclamide)

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8
Q

What is the step-wise drug Mx of T2DM?

A

Metformin
+ sulfonylurea
+ DPP4 inhibitor OR GLP-1 analogue

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9
Q

What value for a fasting plasma glucose is diagnostic of diabetes mellitus?

A

> 7 mmol/L

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11
Q

What value for HbA1c is diagnostic of diabetes mellitus?

A

> 6.5% or 48 mmol/mol

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12
Q

What do all GLP-1 analogues start or end with?

A

End with “-tide” (eg exenatide)

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13
Q

If a diabetes drug ends with “-tide”, what class is it?

A

GLP-1 analogue (eg exenatide)

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14
Q

What do all DPP4 inhibitors start or end with?

A

End with “-gliptin” (eg sitagliptin)

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15
Q

What value for a 2-hour oral glucose test is diagnostic of diabetes mellitus?

A

> 11.1 mmol/L

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16
Q

In which patients is metformin contraindicated and why?

A

Renal failure. Can cause lactic acidosis

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17
Q

What is exenatide?

A

GLP-1 analogue

18
Q

What is glibenclamide?

A

Sulfonylurea

19
Q

what are the guidelines regarding insulin use (in a T1DM) prior to surgery?

A

take half the dose of long acting insulin on the morning of the surgery only

20
Q

what are the guidelines regarding metformin use prior to surgery?

A

Stop 48 hours before

21
Q

what is the fasting blood glucose target for diabetics for surgery?

A

5-10mmol/L

22
Q

what are the guidelines regarding sulfonylureas use prior to surgery?

A

withhold 12 hours prior to surgery

23
Q

what are the guidelines regarding DPP4 inhibitors, SGLT2 inhibitors and GLP-1 analogues use prior to surgery?

A

withhold morning of surgery

24
Q

what are the guidelines regarding basal bolus insulin use prior to surgery?

A

give basal insulin (normal or 2/3) and then give bolus with breakfast if afternoon surgery. Also give IV 5% dextrose

25
Q

What are the side effects of sulphonylureas?

A

Weight gain and hypoglycaemia

26
Q

What is the most common precipitating event for diabetic ketoacidosis?

A

Infection

27
Q

What is the target blood pressure in DM?

A

130/80

28
Q

What is the target HDL in DM?

A

Greater than 1.0

29
Q

What is the target LDL in DM?

A

Less than 2.0

30
Q

What is the target total cholesterol in DM?

A

Less than 4.0