Diabetes mellitus Flashcards
If a diabetes drug begins with “Gli-“, what class is it?
Sulfonylurea (eg glibenclamide)
What value for a random plasma glucose is diagnostic of diabetes mellitus?
> 11.1 mmol/L + symptoms
What do all SGLT2 inhibitor drug names start or end with?
End with “-aglifozin”
What is the range for impaired fasting blood glucose?
6.1-6.9 mmol/L
If a diabetes drug ends with “-aglifozin”, what class is it?
SGLT2 inhibitor
If a diabetes drug ends with “-gliptin”, what class is it?
DPP4 inhibitor (inhibits degradation of GLP-1) (eg sitagliptin)
What do all sulfonylurea drugs start or end with?
Start with “Gli-“ (eg glibenclamide)
What is the step-wise drug Mx of T2DM?
Metformin
+ sulfonylurea
+ DPP4 inhibitor OR GLP-1 analogue
What value for a fasting plasma glucose is diagnostic of diabetes mellitus?
> 7 mmol/L
What value for HbA1c is diagnostic of diabetes mellitus?
> 6.5% or 48 mmol/mol
What do all GLP-1 analogues start or end with?
End with “-tide” (eg exenatide)
If a diabetes drug ends with “-tide”, what class is it?
GLP-1 analogue (eg exenatide)
What do all DPP4 inhibitors start or end with?
End with “-gliptin” (eg sitagliptin)
What value for a 2-hour oral glucose test is diagnostic of diabetes mellitus?
> 11.1 mmol/L
In which patients is metformin contraindicated and why?
Renal failure. Can cause lactic acidosis