Diabetes Mellitus 1

Question 1

Humulin R

Answer 1

human insulin (same amino acid sequence)

short acting, bolus insulin (after meals)

Question 2

Isophan

Answer 2

intermediate acting, human insulin

basal insulin, added with protamine/zinc to prolong duration of action

Question 3

Lente/ Ultralente

Answer 3

long acting human insulin

basal insulin added with protamine/zinc to prolong duration of action

Question 4

Glargine

Answer 4

long acting insulin analogue (altered insulin)

precipitates at site of injection (subcutaneous), prolonged effect

Question 5

Lispro

Answer 5

rapid acting insulin analogue

mimics prandial release of insulin, injected subcutaneously/intravenously

Question 6

Adverse effects

Answer 6

hypoglycemia
lipodystrophy (immune reaction causing atrophy of subcutaneous fatty tissue) at injection sites (change site)
insulin resistance
allergies