Diabetes

Question 1

Type 1 DM?

Answer 1

• Insulin deficiency from AI destruction of pancreatic beta cells
• Associated with other AI diseases

Question 2

Type 2 DM?

Answer 2

Decreased insulin secretion and insulin resistance

Question 3

How can you differentiate between T1DM and T2DM in genetics?

Answer 3

• T1DM - HLA linked
• T2DM - No HLA association

Question 4

How can you differentiate between T1DM and T2DM in genetics?

Answer 4

• T1DM
  
  • Polydipsia, polyuria, ketosis, weight loss
• T2DM
  
  • Asymptomatic, MI

Question 5

What tests can be used to differentiate between t1dm and t2dm?

Answer 5

• T1DM
  
  • IA2 and GAD antibodies
  • Ketones more likely
• T2DM
  
  • C peptide is marker of endogenous insulin release

Question 6

Type 2 diabetes interventions?

Answer 6

• Lifestyle interventions
  
  • Stop smoking
  • Lose weight
  • More exercise
• Metformin
• Other hypoglycaemics