Development of nervous system Flashcards
When does human brain development begin?
3rd week post conception
What is the time period of embryonic development?
0-9weeks
What is the time period of fetal development?
9-40/42 weeks
What is gastrulation?
The development of the 3 layered embryo
What are the 3 layers formed in gastrulation?
Ectoderm
Mesoderm
Endoderm
What does the ectoderm go on to form?
Skin, nails, hair and neural tissue
What does the mesoderm go on to form?
Muscle, bone, cartilage and vascular system
What does the endoderm go on to form?
Gut and resp system
When does the neural tube form?
Days 20-27
What lines the inside of the neural tube?
Neural progenitors
Where is the high concentration of Pax6?
Anterior /rostral pat of brain
Where is the highest concentration of Emx2?
Posterior/caudal part of brain
When do the primary sulci develop in the brain?
Week 8-26
Where do progenitor cells remain during development?
Ventricular zone
Where do neurones migrate to in the fetal period?
Neocortex
When does myelination occur?
Postnatally
What is anencephaly?
Absence of a major portion of the brain that occurs during embryonic development
Results from neural tube defect
What is spina bifida?
Neural tube birth defect/
Bones of the spine don’t form properly around the spine - gap in spine
What is the name of the predominant myelin protein persent in the CNS?
Transmembrane proteolipid protein encoded by PLP1
What chromosome is the PLP1 gene found on?
X chromosome
