Design of Dosage Regimen

Question 1

Refers to the plasma drug concentration that will produce the desired therapeutic effect

Answer 1

Target concentration

Question 2

Refers to the concentration where the drug elimination will equal the rate of drug availability

Answer 2

Steady-state concentration (Css)

Question 3

Refers to a series of repetitive doses to maintain a steady-state concentration of drug

Answer 3

Maintenance dose

Question 4

Refers to one dose or a series of doses given at the onset of therapy with the aim of achieving the target concentration rapidly

Answer 4

Loading dose

Question 5

Formula for dosing rate

Answer 5

(CL x Css) / F

Question 6

Formula for maintenance dose

Answer 6

Dosing rate x Dosing interval

Question 7

Formula for loading dose

Answer 7

(TC x Vd) / F

Question 8

Meaning of CL

Answer 8

Drug clearance

Question 9

Meaning of Css

Answer 9

Steady-state concentration

Question 10

Meaning of F

Answer 10

Bioavailability

Question 11

Meaning of Vd

Answer 11

Volume of distribution

Question 12

Meaning of Tc

Answer 12

Target concentration