Dermatology

Question 1

What enzyme is deficient in

a) prophyria cutanea tarda
b) erythropoeitic protoporphyria
c) acute intermittent porphyria

Answer 1

a) uroporphyrinogen decarboxylase
b) ferrochelatase
c) PBG deaminase

Question 2

What is there a build-up of in porphyria cutanea tarda?

Answer 2

uroporhyrinogen III

Question 3

Treatment of acne rosacea

Answer 3

1st line = topical metronidazole

- then oral tetracycline

Question 4

Treatment of acne vulgaris

Answer 4

benzoyl peroxidase or topical clindamycin

Question 5

What is epidermolysis bullosa?

Answer 5

the break down of anchoring between epidermis and dermis

Question 6

What is pephigus vulgaris?

Answer 6

antibodies target desmosomes causing cells to break apart

- seen as flaacid blisters which burst easily

Question 7

What is bullous pemphigoid?

Answer 7

antibodies target hemidesmosomes causing damage to the basement membrane
- deep tense blisters

Question 8

child crying in direct sunlight

Answer 8

erythropoietic protoporphyria

Question 9

treat cellulitis

Answer 9

staph –> flucloxacillin
strep –> benzylpenicillin
penicillin allergy –> clindamycin

Question 10

impetigo treatment

Answer 10

small area = fusidic acid

widespread = flucloxacillin

Question 11

in what condition is pyoderma gangrenosum seen

Answer 11

IBD

Question 12

what causes steven-johnson syndrome

Answer 12

co-trimoxazole

Question 13

in what disease is livedo reticulans seen

Answer 13

anti phospholipid syndrome

Question 14

Which drugs can cause photosensitivity?

Answer 14

doxycycline, bendroflumethiazide, NSAIDs

Question 15

Which drugs can cause urticaria?

Answer 15

codeine, aspirin and ACE-i

Question 16

itchy vesicles over extensor surfaces

Answer 16

dermatitis herpetiformis

Question 17

which energy source does slow jogging for 40mins use?

Answer 17

glycogen stores

Question 18

A 4-year-old child with multiple painful mouth ulcers, swollen and tender lips and fever.

Answer 18

stomatitis

- caused by HSV

Question 19

Injury to which nerve causes claw hand

Answer 19

ulnar

Question 20

Injury to which nerve causes wrist drop

Answer 20

radial nerve

Question 21

What is there a build-up of in erythropoeitic protoporphyria?

Answer 21

protoporphyrin IX

Question 22

What is there a build-up of in acute intermittent porphyria?

Answer 22

uroporphyrins

Question 23

What is first-line for plaque psoriasis?

Answer 23

potent corticosteroid applied once daily plus vitamin D analogue applied once daily

Question 24

A 25-year-old man presents with a pruritic skin rash. This has been present for the past few weeks and has responded poorly to an emollient cream. The pruritus is described as ‘intense’ and has resulted in him having trouble sleeping. On inspecting the skin you notice a combination of papules and vesicles on his buttocks and the extensor aspect of the knees and elbows. What is the most likely diagnosis?

Answer 24

dermatitis herpetiformis

Question 25

Excisional margins for a Breslow thickness of

a) 0-1mm
b) 1-2mm
c) 2-4mm
d) >4mm

Answer 25

a) 1cm
b) 1-2cm
c) 2-3cm
d) 3cm

Question 26

which antibiotics can cause TEN

Answer 26

penicillins