Dermatology Flashcards
What enzyme is deficient in
a) prophyria cutanea tarda
b) erythropoeitic protoporphyria
c) acute intermittent porphyria
a) uroporphyrinogen decarboxylase
b) ferrochelatase
c) PBG deaminase
What is there a build-up of in porphyria cutanea tarda?
uroporhyrinogen III
Treatment of acne rosacea
1st line = topical metronidazole
- then oral tetracycline
Treatment of acne vulgaris
benzoyl peroxidase or topical clindamycin
What is epidermolysis bullosa?
the break down of anchoring between epidermis and dermis
What is pephigus vulgaris?
antibodies target desmosomes causing cells to break apart
- seen as flaacid blisters which burst easily
What is bullous pemphigoid?
antibodies target hemidesmosomes causing damage to the basement membrane
- deep tense blisters
child crying in direct sunlight
erythropoietic protoporphyria
treat cellulitis
staph –> flucloxacillin
strep –> benzylpenicillin
penicillin allergy –> clindamycin
impetigo treatment
small area = fusidic acid
widespread = flucloxacillin
in what condition is pyoderma gangrenosum seen
IBD
what causes steven-johnson syndrome
co-trimoxazole
in what disease is livedo reticulans seen
anti phospholipid syndrome
Which drugs can cause photosensitivity?
doxycycline, bendroflumethiazide, NSAIDs
Which drugs can cause urticaria?
codeine, aspirin and ACE-i
itchy vesicles over extensor surfaces
dermatitis herpetiformis
which energy source does slow jogging for 40mins use?
glycogen stores
A 4-year-old child with multiple painful mouth ulcers, swollen and tender lips and fever.
stomatitis
- caused by HSV
Injury to which nerve causes claw hand
ulnar
Injury to which nerve causes wrist drop
radial nerve
What is there a build-up of in erythropoeitic protoporphyria?
protoporphyrin IX
What is there a build-up of in acute intermittent porphyria?
uroporphyrins
What is first-line for plaque psoriasis?
potent corticosteroid applied once daily plus vitamin D analogue applied once daily
A 25-year-old man presents with a pruritic skin rash. This has been present for the past few weeks and has responded poorly to an emollient cream. The pruritus is described as ‘intense’ and has resulted in him having trouble sleeping. On inspecting the skin you notice a combination of papules and vesicles on his buttocks and the extensor aspect of the knees and elbows. What is the most likely diagnosis?
dermatitis herpetiformis
