Dermatology

Question 1

TGF-beta

Answer 1

controls fibroblast migration and proliferation
stimulates connective tissue synthesis and remodeling of extracellular matrix

Question 2

Atopic dermatitis pathogenesis

Answer 2

-mutation in epidermal barrier proteins leads to decreased water content, increased permeability, increased inflammation
-immune dysfunction

Question 3

Atopic dermatitis symptoms

Answer 3

Acute: pruritic, erythematous patches and papules
Infants: red extensor surfaces, trunk and face
Children/adults: Flexor surfaces
Chronic: Lichenified plaques

Question 4

Atopic dermatitis associated conditions

Answer 4

allergic rhinitis
asthma
food allergy

Question 5

Atopic dermatitis lab findings

Answer 5

Increased IgE
Eosinophilia

Question 6

Chronic myelogenous leukemia (CML)

Answer 6

Translocation causes BCR gene on chr. 22 to fuse with ABL gene on chr. 9 forming BCR-ABL fusion gene