Dermatological disease

Question 1

What is the Aetiology for Atopic Dermatitis?

Answer 1

• Genetic disposition to become sensitive to allergens
• Have abnormal skin barrier function

Question 2

What is the Pathophysiology for Atopic Dermatitis?

Answer 2

1. Allergens are proteins that when inhaled or absorbed through skin, resp or GI tract
2. Causes allergen-specific IgE production
3. IgE molecules affix to tissue mast cells or basophils
4. When primed cells encounter specific allergen again
5. Mast cell degranulation occurs
6. Resulting in the release of proteolytic enzymes, histamines, bradykins + other vasoactive amines
7. Leading to inflammation (erythema, oedema + puritits)

Question 3

What are the 7 Clinical signs for Atopic Dermatitis?

Answer 3

1. Puritis +++
2. Inflammation
3. Lesions
4. Alopecia
5. Lichenification
6. Erythema
7. Papules

Question 4

What are the Diagnosis for Atopic Dermatitis?

Answer 4

1. Hx
2. Clinical signs
3. Exclusion of other caxuses (Parasites + Infections)
4. Examination
5. Microscopy (Tape, Skin scrape)
6. Bacterial culture
7. Fungal culture
8. Biopsy
9. Exclusion diet
10. Intradermal testing

Question 5

What are the breed dispositions for Atopic Dermatitis?

Answer 5

1. Shar-pei
2. Fox terrier
3. Golden retriever
4. Labrador retriever
5. Dalmation
6. Boxer
7. Boston terrier
8. Lhasa Apso
9. Scottish terrier
10. Shih Tzu
11. WHWT

Question 6

At what age are dogs most suspectible to get Atopic Dermatitis?

Answer 6

Between 6 months + 3 years old

Question 7

What dermatological