Dermatologic Viruses

Question 1

Which virus mimics FMD?

Answer 1

Vesicular Stomatitis Virus

Mucosal vesicles & ulcers; vesicles on udder/coronary band

Question 2

Pathogenesis & transmission of Vesicular stomatitis virus?

Answer 2

Pathogenesis
- infects epithelium -> cytolytic effects -> spreads to draining LNs, but NO viremia // systemic effects!

Transmission
- sand flies, black flies; direct contact
- horses, cattles pigs
- North & Central America; northern regions of South America

Question 3

Virulent factors of FMD?

Answer 3

Non-Enveloped (more resistant to extreme pH, temperature, drugs)

Virus = Aphthovirus, small ssRNA virus

Question 4

Transmission routes of FMD?

Answer 4

Animal movement

Question 5

Pathogenesis of FMD?

Answer 5

• 1º infection via inhalation/ ingestion, inseminationof infectious particles -> viremia -> 2º replication in epitelium cells
• virus shed in secretions before onset of clinical signs - persist in the oropharynx
• horizontal transmission only

Question 6

What signs do all vesicular diseases produce in animals?

Answer 6

Fever w/ vesicles -> progress to erosions in mouth, nares, muzzle, teats, feet

Question 7

Which species are amplifying hosts and mainenance hosts of FMD?

Answer 7

Question 8

What 3 viruses cause epidermal proliferation?

Answer 8

1. Canine Distemper Virus (hyperkeratosis of nose & footpads)
2. Papilloma Virus
3. Pox Virus

Question 9

VF & pathogenesis of papilloma virus?

Answer 9

VF = Non-enveloped

Pathogenesis = Virus replicates in nuceli of basal cells of host’s epithelium -> proliferative warts -> spontaneously regress after weeks-months w/ development of cell-mediated immunity

Question 10

What causes equine sarcoids?

Answer 10

Bovine papillomaviruses 1 & 2 (fibropapillomas)
- Fibroblastic skin tumors
- Most common neoplasms of equine, 1-6 y/o

Question 11

Lesion locations, signalment and characteristics of Canine Oral Papillomas

Answer 11

Lesions: oropharyngeal region (can also occur on conjunctiva, eyelids, muzzle)

Common in young dogs

Spontaneously regress in months

Question 12

Possible sequela of Canine Cutaneous Exophytic and Inverted Papilloma caused by CfPV-2?

Answer 12

Chronic lesions can lead to squamous cell carcinoma

Question 13

Where do pox viruses replicate?

Answer 13

In the cytoplasm

Question 14

Lesions of pox viruses

Answer 14

Question 15

Transmission of Pox viruses?

Answer 15

Aerosol, Direct Contact, Mechanical (insects)